中国儿童多态性与神经母细胞瘤风险的关联
Associations Between Polymorphisms and Neuroblastoma Risk in Chinese Children.
作者信息
Liu Peiqi, Li Yue, Li Yong, Li Li, Cheng Jiwen, Li Suhong, Zhang Jiao, Zhou Haixia, Huo Yunlong, Yang Zhonghua, He Jing, Zhang Ran
机构信息
Department of Pediatric Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning, 110004, People's Republic of China.
Department of Pediatric Surgery, Hunan Children's Hospital, Changsha, Hunan, 410007, People's Republic of China.
出版信息
Pharmgenomics Pers Med. 2025 May 27;18:143-151. doi: 10.2147/PGPM.S488314. eCollection 2025.
BACKGROUND
Neuroblastoma (NB) is a malignancy of neural crest cells that primarily affects children. Single nucleotide polymorphisms (SNPs) in the fat mass and obesity-associated () gene, a well-conserved gene, have been implicated in tumorigenesis. However, there is currently insufficient evidence to establish the relationship between gene SNPs and susceptibility to NB.
METHODS
A TaqMan assay was conducted to examine the potential associations between gene SNPs and the risk of NB in a cohort of 898 patients and 1734 controls from eight medical centers in China. Additionally, stratification analysis was performed to evaluate the relationship between the selected SNPs and the susceptibility to NB among various subgroups.
RESULTS
No significant association was found between the selected polymorphisms and the risk of NB in either the single locus analysis or the combined analysis.
CONCLUSION
However, our study reveals that individuals with retroperitoneal NB and those with stage III+IV NB are more prone to exhibit SNPs compared to other patients. Moreover, participants with the rs8047395 GG genotype displayed a higher likelihood of developing stage III+IV NB in comparison to other participants.
背景
神经母细胞瘤（NB）是一种主要影响儿童的神经嵴细胞恶性肿瘤。脂肪量和肥胖相关基因（）是一个高度保守的基因，其单核苷酸多态性（SNP）与肿瘤发生有关。然而，目前尚无足够证据证实该基因SNP与NB易感性之间的关系。
方法
采用TaqMan分析方法，对来自中国八个医疗中心的898例患者和1734例对照组成的队列进行研究，以检验该基因SNP与NB风险之间的潜在关联。此外，进行分层分析以评估所选SNP与各亚组中NB易感性之间的关系。
结果
在单基因座分析或联合分析中，所选多态性与NB风险之间均未发现显著关联。
结论
然而，我们的研究表明，与其他患者相比，腹膜后NB患者和III + IV期NB患者更易出现该基因SNP。此外，与其他参与者相比，具有该基因rs8047395 GG基因型的参与者发生III + IV期NB的可能性更高。
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