Xiong Boyu, Shao Xinxin, Fang Guangxu, Dong Mengmeng, Han Haobo, Li Quanshun
Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun 130012, China.
Center for Supramolecular Chemical Biology, Jilin University, Changchun 130012, China.
Asian J Pharm Sci. 2025 Apr;20(2):101008. doi: 10.1016/j.ajps.2024.101008. Epub 2024 Dec 11.
Herein, porous poly(lactic-co-glycolic acid) (PLGA) microspheres were prepared to load icariin and miR-23b for the treatment of metastatic lung cancer. The microspheres exhibited desirable aerodynamic diameter, high drug loading and encapsulation efficiency, as well as a favorable drug release profile, which was beneficial for the deposition and exposure of drugs in the lung tissues. The release solution from microspheres exhibited a favorable anti-proliferative effect by inducting cell apoptosis and arresting the cell cycle at G1 phase, and meanwhile inhibited the migration and invasion of cancer cells. More importantly, the microspheres could be effectively inhaled and accumulated in the lung tissues to trigger the apoptosis of tumor cells and suppress metastasis, using mice bearing melanoma-metastatic lung cancer as a model. Furthermore, inhalation of the microspheres showed favorable biocompatibility, barely causing tissue damage. Overall, porous PLGA microspheres provide a promising platform for the inhalable co-delivery of drugs and genes to obtain ideal therapeutic efficacy in lung cancer and other pulmonary diseases.
在此，制备了多孔聚乳酸-乙醇酸共聚物（PLGA）微球来负载淫羊藿苷和miR-23b以治疗转移性肺癌。这些微球具有理想的空气动力学直径、高载药量和包封率，以及良好的药物释放曲线，这有利于药物在肺组织中的沉积和暴露。微球的释放溶液通过诱导细胞凋亡和使细胞周期停滞在G1期表现出良好的抗增殖作用，同时抑制癌细胞的迁移和侵袭。更重要的是，以携带黑色素瘤转移性肺癌的小鼠为模型，微球可有效吸入并积聚在肺组织中以触发肿瘤细胞凋亡并抑制转移。此外，吸入微球显示出良好的生物相容性，几乎不会造成组织损伤。总体而言，多孔PLGA微球为药物和基因的可吸入联合递送提供了一个有前景的平台，以在肺癌和其他肺部疾病中获得理想的治疗效果。
