Denkins Jacob, Babiarz Jane, Ham YoungYoon, Ryu HaYoung, Ricci Brian, Williams Carissa, Alexander Ian, Tucker Kendall, McCrary L Madeline, Levander Ximena
Department of Pharmacy, Oregon Health & Science University, Portland, Oregon, USA.
Division of Internal Medicine and Geriatrics, Department of Medicine, Oregon Health & Science University, Portland, Oregon, USA.
Open Forum Infect Dis. 2025 Apr 24;12(6):ofaf237. doi: 10.1093/ofid/ofaf237. eCollection 2025 Jun.
People who use drugs (PWUD) are increasingly acquiring and transmitting hepatitis C virus (HCV) and being admitted to the hospital for often costly non-HCV-related conditions. Traditionally, treatment of HCV has been deferred to the outpatient setting. However, outpatient HCV follow-up can be an arduous process to navigate with resultant gaps in care, especially for PWUD with numerous complex psychosocial and medical comorbidities. Hospitalization presents a key opportunity to initiate treatment, and several institutions have piloted inpatient treatment models with intensive outreach. We conducted a narrative review of peer-reviewed literature (2014-2024) evaluating hospital-based HCV treatment models for PWUD; 6 studies from 4 countries met inclusion criteria. Evidence suggests that engaging PWUD during hospitalization leads to higher treatment initiation and completion as compared with standard-of-care outpatient referral. Inpatient HCV treatment models should be one part of a comprehensive plan in the United States and internationally to eliminate HCV for all.
吸毒者越来越多地感染并传播丙型肝炎病毒（HCV），并因通常费用高昂的非 HCV 相关病症而住院。传统上，HCV 的治疗一直推迟到门诊进行。然而，门诊 HCV 随访可能是一个艰难的过程，会导致护理出现缺口，尤其是对于患有众多复杂心理社会和医疗合并症的吸毒者。住院治疗为启动治疗提供了一个关键机会，一些机构已经试点了具有强化外展服务的住院治疗模式。我们对 2014 年至 2024 年评估针对吸毒者的基于医院的 HCV 治疗模式的同行评审文献进行了叙述性综述；来自 4 个国家的 6 项研究符合纳入标准。有证据表明，与标准护理门诊转诊相比，在住院期间让吸毒者参与治疗会导致更高的治疗启动率和完成率。在美国和国际上，住院 HCV 治疗模式应该成为消除所有人 HCV 的综合计划的一部分。
