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动脉粥样硬化中血管归巢CD8 T细胞的机制及影响

Mechanisms and implications of vascular-homing CD8 T cells in atherosclerosis.

作者信息

Su Xi, O'Hare Katelyn A, Freeman Michael L

机构信息

Rustbelt Center for AIDS Research, Division of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH USA.

Present Address: Institute for Immunology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA USA.

出版信息

NPJ Cardiovasc Health. 2025;2(1):19. doi: 10.1038/s44325-025-00056-8. Epub 2025 May 28.

DOI:10.1038/s44325-025-00056-8
PMID:40454002
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12119338/
Abstract

CD8 T cells likely contribute to atherosclerosis. Here, we review the relationship of vascular-homing CD8 T cells to atherosclerotic cardiovascular disease, with discussions of atherogenic and atheroprotective CD8 T cell subsets, encompassing their origin, activation, antigen-specificity, trafficking, and functionality. Furthermore, we explore factors that promote CD8 T cell vascular-homing phenotypes, such as infections and inflammation, and describe innovative therapeutic strategies targeting vascular-homing CD8 T cells in people with atherosclerosis.

摘要

CD8 T细胞可能在动脉粥样硬化中发挥作用。在此，我们综述血管归巢性CD8 T细胞与动脉粥样硬化性心血管疾病的关系，讨论促动脉粥样硬化和抗动脉粥样硬化的CD8 T细胞亚群，包括它们的起源、激活、抗原特异性、迁移和功能。此外，我们探讨促进CD8 T细胞血管归巢表型的因素，如感染和炎症，并描述针对动脉粥样硬化患者血管归巢性CD8 T细胞的创新治疗策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/586e/12119338/cd7141ef6508/44325_2025_56_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/586e/12119338/cd7141ef6508/44325_2025_56_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/586e/12119338/cd7141ef6508/44325_2025_56_Fig1_HTML.jpg

相似文献

[1]
Mechanisms and implications of vascular-homing CD8 T cells in atherosclerosis.

NPJ Cardiovasc Health. 2025

[2]
The many faces of CD8+ T cells in atherosclerosis.

Curr Opin Lipidol. 2018-10

[3]
Protective and pathogenic roles of CD8 T cells in atherosclerosis.

Basic Res Cardiol. 2016-11

[4]
T Cells in Atherosclerosis: Key Players in the Pathogenesis of Vascular Disease.

Cells. 2023-8-26

[5]
Association of T-Cell Phenotypes With Peri-Coronary Inflammation in People With and Without HIV and Without Cardiovascular Disease.

Circ Cardiovasc Imaging. 2025-1

[6]
CD39 identifies a microenvironment-specific anti-inflammatory CD8 T-cell population in atherosclerotic lesions.

Atherosclerosis. 2019-4-11

[7]
Direct CD137 costimulation of CD8 T cells promotes retention and innate-like function within nascent atherogenic foci.

Am J Physiol Heart Circ Physiol. 2019-6-1

[8]
T cell subsets and functions in atherosclerosis.

Nat Rev Cardiol. 2020-3-16

[9]
Clonally expanded memory CD8 T cells accumulate in atherosclerotic plaques and are pro-atherogenic in aged mice.

Nat Aging. 2023-12

[10]
CD8 T Cells Drive Plaque Smooth Muscle Cell Dedifferentiation in Experimental Atherosclerosis.

Arterioscler Thromb Vasc Biol. 2024-8

本文引用的文献

[1]
CD57+ T Cell Transmigration Through Vascular Endothelial Cells is Enhanced by Tumor Necrosis Factor: A Novel Model of Cardiovascular Risk in People with HIV.

AIDS Res Hum Retroviruses. 2025-3

[2]
Atherosclerosis antigens as targets for immunotherapy.

Nat Cardiovasc Res. 2023-12

[3]
CD8 T Cells Drive Plaque Smooth Muscle Cell Dedifferentiation in Experimental Atherosclerosis.

Arterioscler Thromb Vasc Biol. 2024-8

[4]
Single-cell T cell receptor sequencing of paired human atherosclerotic plaques and blood reveals autoimmune-like features of expanded effector T cells.

Nat Cardiovasc Res. 2023

[5]
Trends and Disparities in Treatment and Control of Atherosclerotic Cardiovascular Disease in US Adults, 1999 to 2018.

J Am Heart Assoc. 2024-5-7

[6]
Cytomegalovirus Infection Facilitates the Costimulation of CD57+CD28- CD8 T Cells in HIV Infection and Atherosclerosis via the CD2-LFA-3 Axis.

J Immunol. 2024-1-15

[7]
Clonally expanded memory CD8 T cells accumulate in atherosclerotic plaques and are pro-atherogenic in aged mice.

Nat Aging. 2023-12

[8]
Association of Soluble Markers of Inflammation With Peri-coronary Artery Inflammation in People With and Without HIV Infection and Without Cardiovascular Disease.

Open Forum Infect Dis. 2023-6-27

[9]
Bulk and single-cell characterisation of the immune heterogeneity of atherosclerosis identifies novel targets for immunotherapy.

BMC Biol. 2023-2-28

[10]
Cytotoxic CD8 T cells target citrullinated antigens in rheumatoid arthritis.

Nat Commun. 2023-1-19

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