Early dynamics of chromatin decompaction drive nuclear stiffening.
作者信息
Ivanovska Irena L
机构信息
Molecular and Cell Biophysics Lab, Bioengineering, University of Pennsylvania, Philadelphia, PA 19104.
出版信息
Proc Natl Acad Sci U S A. 2025 Jun 10;122(23):e2508415122. doi: 10.1073/pnas.2508415122. Epub 2025 Jun 2.
Abstract
摘要
相似文献
1
Early dynamics of chromatin decompaction drive nuclear stiffening.染色质解压缩的早期动态变化驱动细胞核变硬。
Proc Natl Acad Sci U S A. 2025 Jun 10;122(23):e2508415122. doi: 10.1073/pnas.2508415122. Epub 2025 Jun 2.
2
Acute chromatin decompaction stiffens the nucleus as revealed by nanopillar-induced nuclear deformation in cells.纳米柱诱导细胞中的核变形揭示，急性染色质解压缩会使细胞核变硬。
Proc Natl Acad Sci U S A. 2025 May 13;122(19):e2416659122. doi: 10.1073/pnas.2416659122. Epub 2025 May 9.
3
Quantitative imaging of chromatin decompaction in living cells.活细胞中染色质解紧缩的定量成像。
Mol Biol Cell. 2018 Jul 15;29(13):1763-1777. doi: 10.1091/mbc.E17-11-0648. Epub 2018 May 17.
4
Reverse Mechanotransduction: Driving Chromatin Compaction to Decompaction Increases Cell Adhesion Strength and Contractility.反向力学转导：驱动染色质的紧缩和解紧缩增加细胞黏附强度和收缩性。
Nano Lett. 2024 Apr 10;24(14):4279-4290. doi: 10.1021/acs.nanolett.4c00732. Epub 2024 Mar 28.
5
Nuclear peripheral chromatin-lamin B1 interaction is required for global integrity of chromatin architecture and dynamics in human cells.核周染色质-核纤层 B1 相互作用对于人细胞中染色质结构和动力学的整体完整性是必需的。
Protein Cell. 2022 Apr;13(4):258-280. doi: 10.1007/s13238-020-00794-8. Epub 2020 Nov 5.
6
Counterion-mediated decompaction of liquid crystalline chromosomes.反离子介导的液晶染色体解压缩。
DNA Cell Biol. 2012 Dec;31(12):1657-64. doi: 10.1089/dna.2012.1708. Epub 2012 Oct 16.
7
Indentation induces instantaneous nuclear stiffening and unfolding of nuclear envelope wrinkles.压痕会导致核包膜褶皱的瞬时核变硬和展开。
Proc Natl Acad Sci U S A. 2023 Sep 5;120(36):e2307356120. doi: 10.1073/pnas.2307356120. Epub 2023 Aug 28.
8
Daxx mediated histone H3.3 deposition on HSV-1 DNA restricts genome decompaction and the progression of immediate-early transcription.Daxx介导的组蛋白H3.3在单纯疱疹病毒1型（HSV-1）DNA上的沉积限制了基因组的解压缩以及早期转录的进程。
bioRxiv. 2024 Aug 15:2024.08.15.608064. doi: 10.1101/2024.08.15.608064.
9
Decompaction of wet granular materials under freeze-thaw cycling.湿颗粒物料在冻融循环下的松散。
Phys Rev E. 2019 Jan;99(1-1):012901. doi: 10.1103/PhysRevE.99.012901.
10
The 20S proteasome activator PA28γ controls the compaction of chromatin.20S 蛋白酶体激活剂 PA28γ 控制染色质的紧缩。
J Cell Sci. 2021 Feb 1;134(3):jcs257717. doi: 10.1242/jcs.257717.
本文引用的文献
1
Acute chromatin decompaction stiffens the nucleus as revealed by nanopillar-induced nuclear deformation in cells.纳米柱诱导细胞中的核变形揭示，急性染色质解压缩会使细胞核变硬。
Proc Natl Acad Sci U S A. 2025 May 13;122(19):e2416659122. doi: 10.1073/pnas.2416659122. Epub 2025 May 9.
2
Replication-dependent histone labeling dissects the physical properties of euchromatin/heterochromatin in living human cells.依赖复制的组蛋白标记解析了活的人类细胞中常染色质/异染色质的物理特性。
Sci Adv. 2025 Mar 28;11(13):eadu8400. doi: 10.1126/sciadv.adu8400.
3
Histone and Chromatin Dynamics Facilitating DNA repair.组蛋白和染色质动力学促进 DNA 修复。
DNA Repair (Amst). 2021 Nov;107:103183. doi: 10.1016/j.dnarep.2021.103183. Epub 2021 Aug 13.
4
Chromatin rigidity provides mechanical and genome protection.染色质刚性提供机械和基因组保护。
Mutat Res. 2020 May-Dec;821:111712. doi: 10.1016/j.mrfmmm.2020.111712. Epub 2020 Jun 17.
5
The Emerging Roles of Heterochromatin in Cell Migration.异染色质在细胞迁移中的新作用
Front Cell Dev Biol. 2020 May 27;8:394. doi: 10.3389/fcell.2020.00394. eCollection 2020.
6
Super-resolution imaging reveals the evolution of higher-order chromatin folding in early carcinogenesis.超分辨率成像揭示了早期癌变中高级染色质折叠的演变。
Nat Commun. 2020 Apr 20;11(1):1899. doi: 10.1038/s41467-020-15718-7.
7
Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage.异染色质驱动的核软化可保护基因组免受机械应激诱导的损伤。
Cell. 2020 May 14;181(4):800-817.e22. doi: 10.1016/j.cell.2020.03.052. Epub 2020 Apr 16.
8
Correlating nuclear morphology and external force with combined atomic force microscopy and light sheet imaging separates roles of chromatin and lamin A/C in nuclear mechanics.利用原子力显微镜和光片成像相结合的方法，将核形态和外力进行关联，从而将染色质和核纤层蛋白 A/C 在核力学中的作用分离开来。
Mol Biol Cell. 2020 Jul 21;31(16):1788-1801. doi: 10.1091/mbc.E20-01-0073. Epub 2020 Apr 8.
9
Emil Heitz, a true epigenetics pioneer.埃米尔·海茨，一位真正的表观遗传学先驱。
Nat Rev Mol Cell Biol. 2019 Oct;20(10):572. doi: 10.1038/s41580-019-0161-z.
10
Nuclear Mechanopathology and Cancer Diagnosis.核机制病理学与癌症诊断
Trends Cancer. 2018 Apr;4(4):320-331. doi: 10.1016/j.trecan.2018.02.009. Epub 2018 Mar 16.
Zotero 插件