在个体发育和衰老过程中平衡造血干细胞的自我更新与分化活性。
Balancing hematopoietic stem cell self-renewal and differentiation activities throughout ontogeny and aging.
作者信息
Yamashita Masayuki, Li Jingjing, Tran Vu L, Haltalli Myriam L R, McKinney-Freeman Shannon, Suda Toshio
机构信息
Division of Experimental Hematology, Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN.
Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia.
出版信息
Exp Hematol. 2025 Sep;149:104820. doi: 10.1016/j.exphem.2025.104820. Epub 2025 May 31.
During fetal development, lifelong hematopoietic stem cells (HSCs) emerge from hemogenic endothelium as a part of the intra-arterial hematopoietic clusters. These definitive HSCs are deemed to colonize and expand in the fetal liver, migrate to the bone marrow, and produce mature blood cells throughout life. However, emerging lines of evidence have challenged this paradigm, and alternative models have been proposed. Moreover, recent studies have revealed expansion of HSCs during aging, which seems counterintuitive to their age-dependent reduction in regenerative capacity. Here, we summarize emerging views on hematopoietic ontogeny and aging, which was the focus of the Summer 2024 International Society for Experimental Hematology (ISEH) webinar.
在胎儿发育过程中，终身造血干细胞（HSCs）从造血内皮细胞中产生，成为动脉内造血簇的一部分。这些定型造血干细胞被认为在胎儿肝脏中定植并扩增，迁移到骨髓，并在一生中产生成熟血细胞。然而，新出现的一系列证据对这一模式提出了挑战，并提出了替代模型。此外，最近的研究揭示了造血干细胞在衰老过程中的扩增，这与其随年龄增长而再生能力下降的现象似乎背道而驰。在这里，我们总结了关于造血发生和衰老的新观点，这是2024年夏季国际实验血液学学会（ISEH）网络研讨会的重点。
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