Mukai H, Sugihara K, Sugiyama M
J Pharmacobiodyn. 1985 May;8(5):329-36. doi: 10.1248/bpb1978.8.329.
From the view points of safety and efficacy of sodium guaiazulene-3-sulfonate (GAS) after oral cavity administration, the absorption behavior of GAS was investigated in rats and rabbits and following results were obtained. 1) GAS was absorbed not from oral cavity but from nasal cavity in rats and rabbits. 2) The in situ perfusion experiments revealed the existence of dose-dependent specific absorption mechanism in the rat small intestine. 3) GAS was absorbed from neither the rat stomach nor the rectum. These facts reveal that GAS transfers into the systemic circulation only through the small intestine after the clinical application to the oral cavity. And these absorption characteristics of GAS are suited for its direct action on the inflamed oral mucosa. When GAS is administered into the oral cavity, the safety is at least the same as that obtained after oral administration.
从口服愈创蓝油烃-3-磺酸钠（GAS）的安全性和有效性角度出发，在大鼠和兔子身上研究了GAS的吸收行为，并获得了以下结果。1）在大鼠和兔子中，GAS不是从口腔吸收，而是从鼻腔吸收。2）原位灌注实验表明大鼠小肠中存在剂量依赖性的特异性吸收机制。3）GAS既不从大鼠胃也不从直肠吸收。这些事实表明，临床应用于口腔后，GAS仅通过小肠进入体循环。并且GAS的这些吸收特性适合于其对发炎口腔黏膜的直接作用。当GAS经口腔给药时，其安全性至少与口服给药后相同。
