下丘脑激素的降解
Degradation of hypothalamic hormones.
作者信息
Bauer K
出版信息
Naunyn Schmiedebergs Arch Pharmacol. 1977;297 Suppl 1:S55-6. doi: 10.1007/BF00587778.
PMID:404575
Abstract
The enzymatic fragmentation of TRH (pyroGlu-His-Pro-NH2) by serum, hypothalamic and hypophyseal tissue was investigated. As primary cleavage product only His-Pro-NH2 was detected when TRH was incubated with serum while with the tissue preparations the formation of His-Pro-NH2, deamido-TRH and prolineamide could be detected as enzymatically formed primary fragments.
摘要
研究了血清、下丘脑和垂体组织对促甲状腺激素释放激素（TRH，焦谷氨酸-组氨酸-脯氨酰胺）的酶促裂解作用。当TRH与血清一起孵育时，仅检测到组氨酸-脯氨酰胺作为主要裂解产物，而在组织制剂中，组氨酸-脯氨酰胺、脱酰胺TRH和脯氨酰胺可被检测为酶促形成的主要片段。
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