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下丘脑激素的降解

Degradation of hypothalamic hormones.

作者信息

Bauer K

出版信息

Naunyn Schmiedebergs Arch Pharmacol. 1977;297 Suppl 1:S55-6. doi: 10.1007/BF00587778.

DOI:10.1007/BF00587778
PMID:404575
Abstract

The enzymatic fragmentation of TRH (pyroGlu-His-Pro-NH2) by serum, hypothalamic and hypophyseal tissue was investigated. As primary cleavage product only His-Pro-NH2 was detected when TRH was incubated with serum while with the tissue preparations the formation of His-Pro-NH2, deamido-TRH and prolineamide could be detected as enzymatically formed primary fragments.

摘要

研究了血清、下丘脑和垂体组织对促甲状腺激素释放激素（TRH，焦谷氨酸-组氨酸-脯氨酰胺）的酶促裂解作用。当TRH与血清一起孵育时，仅检测到组氨酸-脯氨酰胺作为主要裂解产物，而在组织制剂中，组氨酸-脯氨酰胺、脱酰胺TRH和脯氨酰胺可被检测为酶促形成的主要片段。

相似文献

1
Degradation of hypothalamic hormones.下丘脑激素的降解
Naunyn Schmiedebergs Arch Pharmacol. 1977;297 Suppl 1:S55-6. doi: 10.1007/BF00587778.
2
Attempts toward biosynthesis of the thyrotropin-releasing hormone and studies on its breakdown in hypothalamic tissue preparations.促甲状腺激素释放激素的生物合成尝试及其在下丘脑组织制剂中的分解研究。
Endocrinology. 1976 Jul;99(1):230-42. doi: 10.1210/endo-99-1-230.
3
Adenohypophyseal degradation of thyrotropin releasing hormone regulated by thyroid hormones.甲状腺激素调节促甲状腺激素释放激素的腺垂体降解。
Nature. 1987;330(6146):375-7. doi: 10.1038/330375a0.
4
Alterations in levels of thyrotrophin releasing hormone and rates of hormone degradation in hypothalamic tissue of the developing rat.发育中大鼠下丘脑组织中促甲状腺激素释放激素水平及激素降解速率的变化
J Endocrinol. 1980 Apr;85(1):55-61. doi: 10.1677/joe.0.0850055.
5
Testosterone regulates the secretion of thyrotrophin-releasing hormone (TRH) and TRH precursor in the rat hypothalamic-pituitary axis.睾酮调节大鼠下丘脑 - 垂体轴中促甲状腺激素释放激素（TRH）及其前体的分泌。
J Endocrinol. 1990 May;125(2):263-70. doi: 10.1677/joe.0.1250263.
6
Urinary excretion of the TRH-like peptide pyroglutamyl-glutamyl-prolineamide in rats.大鼠中促甲状腺激素释放激素样肽焦谷氨酰-谷氨酰-脯氨酰胺的尿排泄情况。
J Endocrinol. 1997 Jun;153(3):411-21. doi: 10.1677/joe.0.1530411.
7
Further studies on the inactivation of thyrotrophin releasing hormone (TRH) by enzymes in the rat hypothalamus.
Acta Endocrinol (Copenh). 1980 Apr;93(4):385-91. doi: 10.1530/acta.0.0930385.
8
Catabolism of thyroliberin by rat adenohypophyseal tissue extract.大鼠腺垂体组织提取物对促甲状腺素释放素的分解代谢
Eur J Biochem. 1980 May;106(1):107-17. doi: 10.1111/j.1432-1033.1980.tb06001.x.
9
Effect of chronic treatment with thyrotropin-releasing hormone (TRH) or an analog of TRH (linear beta-alanine TRH) on the hypothalamic-pituitary-thyroid axis.促甲状腺激素释放激素（TRH）或TRH类似物（线性β-丙氨酸TRH）长期治疗对下丘脑-垂体-甲状腺轴的影响。
Neuroendocrinology. 1980 Apr;30(4):193-9. doi: 10.1159/000123000.
10
Thyrotropin-releasing hormone-like bioactivity in placenta: evidence for the existence of substances other than Pyroglu-His-Pro-NH2 (TRH) capable of stimulating pituitary thyrotropin release.
Endocrinology. 1980 Feb;106(2):541-6. doi: 10.1210/endo-106-2-541.

本文引用的文献

1
Attempts toward biosynthesis of the thyrotropin-releasing hormone and studies on its breakdown in hypothalamic tissue preparations.促甲状腺激素释放激素的生物合成尝试及其在下丘脑组织制剂中的分解研究。
Endocrinology. 1976 Jul;99(1):230-42. doi: 10.1210/endo-99-1-230.
2
Characteristics of the plasma TRH-degrading enzyme.
Neuroendocrinology. 1975;19(3):277-87.
3
Regulation of degradation of thyrotropin releasing hormone by thyroid hormones.甲状腺激素对促甲状腺激素释放激素降解的调节。
Nature. 1976 Feb 19;259(5544):591-3. doi: 10.1038/259591a0.