İletmiş Gizem, Yaman Gozde Bacik
Department of Psychiatry, Faculty of Medicine Süleyman Demirel University, Isparta, Turkey.
Nord J Psychiatry. 2025 Aug;79(6):417-426. doi: 10.1080/08039488.2025.2511068. Epub 2025 Jun 3.
The aim of this study is to determine the prevalence of misophonia in patients diagnosed with bipolar disorder (BD), examine its relationship with autism spectrum symptoms and emotion regulation skills, and compare it with a healthy control group.
The study included 105 patients diagnosed with BD in remission for at least three months and 105 age-, gender-, and education-matched healthy controls. All participants completed the sociodemographic data form, Hamilton Depression Rating Scale, Young Mania Rating Scale, Revised Amsterdam Misophonia Scale, Emotion Regulation Skills Questionnaire, and Autism Spectrum Quotient.
Misophonia symptoms were statistically significantly more prevalent in the healthy control group (63.8%) than in the BD group (48.6%) ( = 0.026). Among BD patients with misophonia symptoms, a history of suicide attempts and higher autistic traits were statistically significantly more common ( = 0.026, = 0.003, respectively). No statistically significant relationship was found between the severity of misophonia and autism traits ( = 0.200; = 0.159) or emotion regulation skills ( = -0.178; = 0.210). Multivariate regression analyses identified suicide attempt history and autistic traits as significant predictors of misophonia severity.
Misophonia symptoms were more prevalent in control group, contrary to our hypothesis. BD patients exhibited pronounced emotion regulation deficits, which worsened with increased autistic traits. Misophonia symptoms were statistically significantly associated with adverse psychiatric outcomes in BD patients. These findings highlight the importance of assessing misophonia, emotion regulation, and autistic traits collectively in clinical settings, and suggest that addressing misophonia symptoms in treatment planning may enhance patient functioning.
本研究旨在确定双相情感障碍（BD）患者中恐音症的患病率，研究其与自闭症谱系症状及情绪调节技能的关系，并与健康对照组进行比较。
该研究纳入了105名处于缓解期至少三个月的BD患者以及105名年龄、性别和教育程度相匹配的健康对照者。所有参与者均完成了社会人口统计学数据表、汉密尔顿抑郁量表、杨氏躁狂量表、修订版阿姆斯特丹恐音症量表、情绪调节技能问卷和自闭症谱系商数问卷。
恐音症症状在健康对照组中的发生率（63.8%）在统计学上显著高于BD组（48.6%）（P = 0.026）。在有恐音症症状的BD患者中，自杀未遂史和较高的自闭症特征在统计学上显著更为常见（分别为P = 0.026，P = 0.003）。未发现恐音症严重程度与自闭症特征（P = 0.200；P = 0.159）或情绪调节技能之间存在统计学上的显著关系（P = -0.178；P = 0.210）。多变量回归分析确定自杀未遂史和自闭症特征是恐音症严重程度的重要预测因素。
与我们的假设相反，恐音症症状在对照组中更为普遍。BD患者表现出明显的情绪调节缺陷，且随着自闭症特征的增加而恶化。恐音症症状在统计学上与BD患者的不良精神科结局显著相关。这些发现凸显了在临床环境中综合评估恐音症、情绪调节和自闭症特征的重要性，并表明在治疗计划中解决恐音症症状可能会改善患者的功能。
