Kahaleh M B, Scharstein K K, LeRoy E C
J Rheumatol. 1985 Jun;12(3):468-71.
The effect of plasma on platelet adhesion to collagen coated microtiter wells was investigated in 22 patients with scleroderma and 26 control subjects. In the control subjects, platelet adhesion was 38 +/- 13% (mean +/- SD) of adhesion with buffer alone; in scleroderma patients adhesion was 64 +/- 20% (p less than 0.001). No correlation was seen between the effect of plasma on platelet adhesion to collagen and the plasma levels of either FVIII/von Willebrand factor antigen or fibronectin in either scleroderma or control subjects. Furthermore, scleroderma platelets demonstrated enhanced adhesion compared to control platelets when tested in the presence of either control or scleroderma plasma.
在22例硬皮病患者和26名对照受试者中研究了血浆对血小板黏附于胶原包被的微量滴定孔的影响。在对照受试者中，血小板黏附率为单独使用缓冲液时黏附率的38±13%（平均值±标准差）；在硬皮病患者中，黏附率为64±20%（p<0.001）。在硬皮病患者或对照受试者中，血浆对血小板黏附于胶原的影响与FVIII/血管性血友病因子抗原或纤连蛋白的血浆水平之间均未发现相关性。此外，当在对照血浆或硬皮病血浆存在的情况下进行测试时，硬皮病血小板与对照血小板相比表现出增强的黏附性。
