一例遗传性α-类胰蛋白酶血症及疑似嗜酸性肉芽肿性多血管炎病例。
A case of hereditary alpha tryptasemia and presumptive eosinophilic granulomatosis with polyangiitis.
作者信息
Iqbal Sonia, Baxter Joseph A, Adams Karla E
机构信息
Department of Internal Medicine, Malcolm Grow Medical Center, Joint Base Andrews, Md.
Department of Allergy and Immunology, 56th Medical Group, Luke Air Force Base, Ariz.
出版信息
J Allergy Clin Immunol Glob. 2025 Apr 22;4(3):100481. doi: 10.1016/j.jacig.2025.100481. eCollection 2025 Aug.
This case is notable for the potential overlap of hereditary alpha tryptasemia and eosinophilic granulomatosis with polyangiitis. The successful use of mepolizumab, initially for eosinophilic granulomatosis with polyangiitis but potentially benefiting the patient's hereditary alpha tryptasemia, offers a novel approach to managing complex cases involving both rare disorders.
该病例的显著之处在于遗传性α-类胰蛋白酶血症与嗜酸性肉芽肿性多血管炎可能存在重叠。美泊利单抗的成功使用，最初用于治疗嗜酸性肉芽肿性多血管炎，但可能对患者的遗传性α-类胰蛋白酶血症有益，为处理涉及这两种罕见疾病的复杂病例提供了一种新方法。
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