Önner Hasan, Kılınçer Abidin
Selçuk University Institute of Social Sciences, Faculty of Medicine, Department of Nuclear Medicine, Konya, Türkiye.
Selçuk University Institute of Social Sciences, Department of Radiology, Konya, Türkiye.
Mol Imaging Radionucl Ther. 2025 Jun 3;34(2):129-131. doi: 10.4274/mirt.galenos.2024.93270.
We present the Ga-prostate-specific membrane antigen (PSMA) and Ga-fibroblast activation protein inhibitor (FAPI)-04 positron emission tomography/computed tomography (PET/CT) findings comparatively of a 76-year-old man with a history of progressive dyspnea and evidence of interstitial lung disease (ILD) abnormalities on high-resolution CT. Moderate PSMA uptake was observed in areas with ILD abnormalities on Ga-PSMA PET/CT. Ga-FAPI-04 PET/CT showed relatively higher FAPI-04 uptake in these regions. These findings offer the potential to assess disease activity at the cellular and molecular levels. This approach may provide valuable insight into the pathophysiology of ILD beyond the structural changes captured by traditional imaging methods.
我们展示了一名76岁男性的镓-前列腺特异性膜抗原（PSMA）和镓-成纤维细胞激活蛋白抑制剂（FAPI）-04正电子发射断层扫描/计算机断层扫描（PET/CT）结果，该患者有进行性呼吸困难病史，高分辨率CT显示间质性肺疾病（ILD）异常。在镓-PSMA PET/CT上，ILD异常区域观察到中度PSMA摄取。镓-FAPI-04 PET/CT显示这些区域的FAPI-04摄取相对较高。这些发现为在细胞和分子水平评估疾病活动提供了潜力。这种方法可能为ILD的病理生理学提供有价值的见解，超越传统成像方法所捕捉到的结构变化。
