Zhao Mingyuan, Xiang Jiawei, Meng Yuan, Sun Huizhen, Yang Wenxiao, Li Zhongxian, Li Kai, Zhang Qiang, Ao Zhuo, Han Dong
CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China.
University of Chinese Academy of Sciences, Beijing 100049, China.
ACS Nano. 2025 Jun 17;19(23):21571-21588. doi: 10.1021/acsnano.5c03744. Epub 2025 Jun 3.
The regulation of the immune microenvironment is a key component of wound healing, where suitable wound dressings with skin immunoreactivity can favorably affect the immune process and promote the repairing progress. Therefore, we developed an injectable photo-cross-linkable composite hydrogel─oxidized astragalus polysaccharide and carboxymethyl chitosan/sodium methacrylated alginate and magnesium ions hydrogel (OAPS-CMC/SAMA-Mg, OCS) loaded with curcumin (Cur)-encapsulated supramolecular self-assemblies (NX SSA) (NX@Cur)─termed OCS/NX@Cur to synergistically accelerate skin repair. The astragalus polysaccharide-dominated hydrogel matrix provided a superior anti-inflammatory ability. Meanwhile, NX@Cur provided strong angiogenesis and accelerated collagen deposition. In cellular experiments and a rat model of total skin defects, the OCS/NX@Cur exhibited superior anti-inflammatory, antioxidant, and angiogenic capabilities. These properties modulated the inflammatory environment of the wound, thereby promoting the formation of granulation tissue and neovascularization and accelerating collagen deposition and re-epithelialization. In conclusion, OCS/NX@Cur showed excellent wound repair capabilities, providing a potential therapeutic option for the combination of super self-assembly and natural polysaccharide hydrogels for wound repair.
免疫微环境的调节是伤口愈合的关键组成部分，具有皮肤免疫反应性的合适伤口敷料可以对免疫过程产生有利影响并促进修复进程。因此，我们开发了一种可注射的光交联复合水凝胶——负载姜黄素（Cur）包裹的超分子自组装体（NX SSA）（NX@Cur）的氧化黄芪多糖和羧甲基壳聚糖/甲基丙烯酸化海藻酸钠和镁离子水凝胶（OAPS-CMC/SAMA-Mg，OCS）——称为OCS/NX@Cur，以协同加速皮肤修复。以黄芪多糖为主的水凝胶基质具有卓越的抗炎能力。同时，NX@Cur具有强大的血管生成作用并加速胶原蛋白沉积。在细胞实验和大鼠全层皮肤缺损模型中，OCS/NX@Cur表现出卓越的抗炎、抗氧化和血管生成能力。这些特性调节了伤口的炎症环境，从而促进肉芽组织形成和新血管生成，并加速胶原蛋白沉积和上皮再形成。总之，OCS/NX@Cur显示出优异的伤口修复能力，为超分子自组装体与天然多糖水凝胶联合用于伤口修复提供了一种潜在的治疗选择。
