Turner Casey G, DuPont Jennifer J
Molecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts, United States.
Am J Physiol Heart Circ Physiol. 2025 Jul 1;329(1):H217-H232. doi: 10.1152/ajpheart.00174.2025. Epub 2025 Jun 3.
This review article summarizes the current literature investigating the effects of transient sex hormone fluctuations on large artery endothelial function, primarily concerning the menstrual cycle and the diurnal rhythm of testosterone secretion. Women and men experience acute fluctuations in circulating levels of sex hormones, and there is substantial variability in circulating levels of sex hormones in both sexes. These acute fluctuations in sex hormones generally coincide with alterations in endothelial cell function and in vivo endothelium-dependent vasodilation, and we see that the timing of these acute fluctuations matches the timing of cardiovascular events in both women and men. It is important to improve our understanding of how acute fluctuations in sex hormones affect endothelial function in women and men, as clinical cardiovascular complications coincide with these changes. This would allow for the identification of novel therapeutic targets and aid in the prevention and treatment of cardiovascular disease.
这篇综述文章总结了当前关于瞬时性激素波动对大动脉内皮功能影响的文献，主要涉及月经周期和睾酮分泌的昼夜节律。女性和男性都会经历循环性激素水平的急性波动，并且两性的循环性激素水平都存在很大差异。这些性激素的急性波动通常与内皮细胞功能和体内内皮依赖性血管舒张的改变同时发生，而且我们发现这些急性波动的时间与女性和男性心血管事件的时间相匹配。鉴于临床心血管并发症与这些变化同时出现，因此提高我们对性激素急性波动如何影响女性和男性内皮功能的理解非常重要。这将有助于确定新的治疗靶点，并有助于预防和治疗心血管疾病。
