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Roles of TLR9: Gatekeeper to fungal infections.

作者信息

da Silva-Junior Elias Barbosa, Freire-de-Lima Leonardo, Covre Luciana Polaco, Morrot Alexandre, de Matos Guedes Herbert Leonel, Decote-Ricardo Debora, Freire-de-Lima Celio Geraldo

机构信息

Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

Núcleo de Doenças Infecciosas, Universidade Federal do Espírito Santo, Vitória, Brazil.

出版信息

PLoS Pathog. 2025 Jun 3;21(6):e1013185. doi: 10.1371/journal.ppat.1013185. eCollection 2025 Jun.

DOI:10.1371/journal.ppat.1013185
PMID:40460068
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12132989/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b9d/12132989/a61783f0d18b/ppat.1013185.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b9d/12132989/59a80cf18313/ppat.1013185.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b9d/12132989/a61783f0d18b/ppat.1013185.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b9d/12132989/59a80cf18313/ppat.1013185.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b9d/12132989/a61783f0d18b/ppat.1013185.g002.jpg

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本文引用的文献

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Lack of Toll-Like Receptor 9 Exacerbates Ocular Impairment and Visual Loss During Systemic Cryptococcus gattii Infection.Toll样受体9的缺失会加剧全身性加氏隐球菌感染期间的眼部损伤和视力丧失。
J Infect Dis. 2025 Jul 11;231(6):1597-1608. doi: 10.1093/infdis/jiaf034.
2
IL-6 deficiency accelerates cerebral cryptococcosis and alters glial cell responses.IL-6 缺乏加速脑部隐球菌病并改变神经胶质细胞反应。
J Neuroinflammation. 2024 Sep 27;21(1):242. doi: 10.1186/s12974-024-03237-x.
3
A human commensal-pathogenic fungus suppresses host immunity via targeting TBK1.
一种人类共生-致病真菌通过靶向 TBK1 抑制宿主免疫。
Cell Host Microbe. 2024 Sep 11;32(9):1536-1551.e6. doi: 10.1016/j.chom.2024.07.003. Epub 2024 Jul 30.
4
TLR9 promotes monocytic myeloid-derived suppressor cell induction during JEV infection.TLR9 促进 JEV 感染期间单核细胞来源的髓系抑制细胞的诱导。
Microbes Infect. 2024 Jul-Aug;26(5-6):105336. doi: 10.1016/j.micinf.2024.105336. Epub 2024 May 7.
5
s rapidly invades the murine brain by sequential breaching of airway and endothelial tissues barriers, followed by engulfment by microglia.它通过连续突破气道和内皮组织屏障迅速入侵小鼠大脑，随后被小胶质细胞吞噬。
mBio. 2024 Apr 10;15(4):e0307823. doi: 10.1128/mbio.03078-23. Epub 2024 Mar 21.
6
The IRAK1/IRF5 axis initiates IL-12 response by dendritic cells and control of Toxoplasma gondii infection.IRAK1/IRF5 轴通过树突状细胞启动 IL-12 反应，并控制弓形体感染。
Cell Rep. 2024 Feb 27;43(2):113795. doi: 10.1016/j.celrep.2024.113795. Epub 2024 Feb 15.
7
Candida albicans extracellular vesicles trigger type I IFN signalling via cGAS and STING.白色念珠菌细胞外囊泡通过 cGAS 和 STING 触发 I 型干扰素信号通路。
Nat Microbiol. 2024 Jan;9(1):95-107. doi: 10.1038/s41564-023-01546-0. Epub 2024 Jan 2.
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Front Immunol. 2023 Sep 1;14:1259989. doi: 10.3389/fimmu.2023.1259989. eCollection 2023.
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