Wang Hao, Gao Lei, Zhang Jin-Lian, Zhong Ling-Yun, Jin Shu-Han, Chen Xiao-Yan, Zhang Wen, Wen Jia-Wen
Jiangxi University of Chinese Medicine Nanchang 330004, China.
Zhongguo Zhong Yao Za Zhi. 2025 May;50(9):2305-2316. doi: 10.19540/j.cnki.cjcmm.20250211.602.
Acori Tatarinowii Rhizoma is the dried rhizome of Acorus tatarinowii in the family of Tennantiaceae, which has the efficacy of opening up the orifices and expelling phlegm, awakening the mind and wisdom, and resolving dampness and opening up the stomach. Modern studies have shown that volatile oil is the main active ingredient of Acori Tatarinowii Rhizoma, and α-asarone and β-asarone have been proved to be the active ingredients in the volatile oil of Acori Tatarinowii Rhizoma, with pharmacological effects such as anti-Alzheimer's disease, antiepileptic, anti-Parkinson's disease, antidepressant, anticerebral ischemia/reperfusion injury, anti-thrombosis, lipid-lowering, and antitumor. By summarising and outlining the pharmacological effects of α-asarone and β-asarone and elucidating the possible mechanisms of their pharmacological effects, we can provide theoretical basis for the further research and clinical application of Acori Tatarinowii Rhizoma.
石菖蒲为天南星科植物石菖蒲的干燥根茎，具有开窍豁痰、醒神益智、化湿开胃之功效。现代研究表明，挥发油是石菖蒲的主要活性成分，α-细辛醚和β-细辛醚已被证明是石菖蒲挥发油中的活性成分，具有抗阿尔茨海默病、抗癫痫、抗帕金森病、抗抑郁、抗脑缺血/再灌注损伤、抗血栓形成、降脂及抗肿瘤等药理作用。通过总结和概述α-细辛醚和β-细辛醚的药理作用并阐明其药理作用的可能机制，可为石菖蒲的进一步研究和临床应用提供理论依据。
