Zhou Wenjie, Mao Chuanqing, Shi Ge, Lu Meng, Lai Yongzhen, Wang Chengyong, Li Yilin, Chen Weihui
Department of Oral and Maxillofacial Surgery, Fujian Medical University Union Hospital, No. 29 Xinquan Road, Fuzhou, 350001, Fujian, China.
Fujian Key Laboratory of Oral Diseases & Fujian Provincial Engineering Research Center of Oral Biomaterial & Stomatological Key Laboratory of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, No.88 Jiaotong Road, Fuzhou, 350002, Fujian, China.
Sci Rep. 2025 Jun 3;15(1):19482. doi: 10.1038/s41598-025-04816-5.
Jaw cysts commonly affect the oral and maxillofacial region. This study aimed to evaluate the effect of Concentrated Growth Factor (CGF) application during jaw cyst surgery on postoperative pulp sensitivity changes in affected teeth. This retrospective cross-sectional study included fifty-one patients with jaw cysts, categorized into four groups based on the postoperative filling material used Group A (CGF), Group B (CGF + Bio-Gene), Group C (Bio-Gene) and Group D (Control). Clinical follow-up data, including electric pulp testing results, tooth color changes, gingival healing status, and radiographic evaluations, were collected at 2 weeks and at 3 to 6 months post-surgery. One-way analysis of variance (Kruskal-Wallis test) and linear regression analysis were employed to analyze bone regeneration, changes in pulp sensitivity, and their potential correlations. Results indicated that pulp sensitivity in affected teeth significantly improved at 6 months post-surgery in Group A and Group B compared to pre-surgery levels, with statistically significant differences (p = 0.04; p = 0.043). Conversely, no significant changes in pulp sensitivity were observed in Group C and Group D before and after surgery (p = 0.29; p = 0.867). Additionally, pulp sensitivity recovery was negatively correlated with age but showed no correlation with Hounsfield unit (Hu) values in the apical region or bone formation rates in the cyst cavity. The application of CGF following cyst enucleation aids in restoring blood circulation in affected teeth with sluggish pulp vitality, thereby enhancing the pulp preservation rate and warranting clinical promotion.
颌骨囊肿常累及口腔颌面部区域。本研究旨在评估颌骨囊肿手术中应用浓缩生长因子（CGF）对患牙术后牙髓敏感性变化的影响。这项回顾性横断面研究纳入了51例颌骨囊肿患者，根据术后填充材料分为四组：A组（CGF）、B组（CGF + 生物基因）、C组（生物基因）和D组（对照组）。在术后2周以及3至6个月收集临床随访数据，包括牙髓电测试结果、牙齿颜色变化、牙龈愈合状况和影像学评估。采用单因素方差分析（Kruskal-Wallis检验）和线性回归分析来分析骨再生、牙髓敏感性变化及其潜在相关性。结果表明，与术前水平相比，A组和B组患牙在术后6个月时牙髓敏感性显著改善，差异具有统计学意义（p = 0.04；p = 0.043）。相反，C组和D组手术前后牙髓敏感性无显著变化（p = 0.29；p = 0.867）。此外，牙髓敏感性恢复与年龄呈负相关，但与根尖区域的亨氏单位（Hu）值或囊肿腔内的骨形成率无关。囊肿摘除术后应用CGF有助于恢复牙髓活力迟缓的患牙血液循环，从而提高牙髓保存率，值得临床推广。
