Yibeltal Kalkidan, Workneh Firehiwot, Fasil Nebiyou, Baye Estifanos, Kang Yunhee, Kidane Workagegnhu Tarekegn, Tsegaye Sitota, Berhane Yoseph Yemane, Haymanot Bethlehem, Olson Ingrid E, Derebe Mulatu Melese, Molina Rose L, Wylie Blair J, Chan Grace J, Christian Parul, Worku Alemayehu, Lee Anne Cc, Berhane Yemane
Department of Reproductive Health and Population, Addis Continental Institute of Public Health, Addis Ababa, Ethiopia.
Department of Epidemiology and Biostatistics, Addis Continental Institute of Public Health, Addis Ababa, Ethiopia.
BMC Res Notes. 2025 Jun 3;18(1):245. doi: 10.1186/s13104-025-07309-w.
This study aimed to assess the prevalence of intestinal parasitic infections among pregnant women in the third trimester who received prior presumptive deworming in 12 health centers in the Amhara region, Ethiopia. This sub-study was part of the parent Enhancing Nutrition and Antenatal Infection Treatment (ENAT) study; a randomized clinical effectiveness study conducted to determine the effectiveness of packages of antenatal interventions to enhance maternal nutrition and infection management on birth outcomes.
Three hundred fifty women provided a stool sample in their 3rd trimester for screening using wet mount microscopy. All women had previously received 500 mg of presumptive mebendazole in the 2nd trimester. One in three women (109/350, 31.0%) were found to have a parasitic stool infection after prior deworming and 15% of women reported gastrointestinal symptoms. The most common infections were Giardia lamblia (n = 43, 37.4%), Entamoeba histolytica (n = 40, 34.8%), and Hookworm (n = 25, 21.7%). Six mothers had co-infections with at least two parasites with trophozoites of Giardia lamblia and Entamoeba histolytica co-infection being dominant.
本研究旨在评估埃塞俄比亚阿姆哈拉地区12个健康中心中，在孕晚期接受过驱虫治疗的孕妇肠道寄生虫感染的患病率。该子研究是母体“加强营养与产前感染治疗”（ENAT）研究的一部分；这是一项随机临床疗效研究，旨在确定一系列产前干预措施对改善孕产妇营养和感染管理以提高分娩结局的有效性。
350名妇女在孕晚期提供了粪便样本，用于湿片显微镜检查筛查。所有妇女在孕中期均曾接受过500毫克的阿苯达唑预防性治疗。三分之一的妇女（109/350，31.0%）在接受过驱虫治疗后被发现粪便中有寄生虫感染，15%的妇女报告有胃肠道症状。最常见的感染是蓝氏贾第鞭毛虫（n = 43，37.4%）、溶组织内阿米巴（n = 40，34.8%）和钩虫（n = 25，21.7%）。6名母亲感染了至少两种寄生虫，其中蓝氏贾第鞭毛虫滋养体和溶组织内阿米巴共同感染最为常见。
