Wang Shan, Hu Miaomiao, Xue Yehua, Chen Yeping, Li Kunpeng, Dong Lu, Liang Libing, Jiang Jieting, Li Xuemin, Wu Caiqin
School of Nursing, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Scientific research department, Shanghai Second Rehabilitation Hospital, Shanghai, 200940, China.
BMC Psychol. 2025 Jun 3;13(1):594. doi: 10.1186/s40359-025-02939-y.
BACKGROUND: Post-stroke cognitive impairment (PSCI) and depression affect over 60% of elderly stroke survivors, severely impairing functional recovery and quality of life. Despite the efficacy of non-pharmacological interventions, evidence on individualized approaches for elderly stroke patients remains limited. This study aims to evaluate the clinical impact of individual reminiscence therapy (RT) on cognitive function, depressive symptoms, and quality of life in elderly stroke survivors. METHODS: A single-blinded, parallel, randomized controlled trial will be conducted with 80 elderly stroke patients recruited from two hospitals in Shanghai. Participants will be randomly assigned to an intervention group receiving eight weeks of individual RT (30-45 min weekly) or a control group receiving standard care with a 1:1 ratio. Cognitive function, including Mini-Mental State Examination (MMSE), Boston Naming Test (BNT), Trail Making Test-A (TMT-A), depressive symptoms assessed by the Patient Health Questionnaire-9 (PHQ-9), and quality of life assessed by the Stroke-Specific Quality of Life Scale (Ss-QoL) will be assessed by blinded evaluators at baseline (T0), post-intervention (8 weeks, T1), and 4-week follow-up (12 weeks, T2). The intervention features a tailored RT protocol allowing patients to select topics (e.g., childhood memories, work life) to enhance engagement. Blinded evaluators will ensure measurement objectivity, and intention-to-treat analysis addressed attrition. DISCUSSION: This study aims to provide a fresh perspective on the effectiveness of individual RT in enhancing cognitive function, reducing depressive symptoms, and improving the quality of life, among stroke patients. The use of a tailored individual RT program based on an in-depth literature review and conceptual analysis, along with a multidimensional assessment system, differentiates this study from previous ones. TRIAL REGISTRATION: This protocol was registered at the Chinese Clinical Trials.gov (Identifier: ChiCTR2500095471) on January 8, 2025.
背景：中风后认知障碍（PSCI）和抑郁症影响着超过60%的老年中风幸存者，严重损害功能恢复和生活质量。尽管非药物干预有效，但关于老年中风患者个体化治疗方法的证据仍然有限。本研究旨在评估个体回忆疗法（RT）对老年中风幸存者认知功能、抑郁症状和生活质量的临床影响。 方法：将对从上海两家医院招募的80名老年中风患者进行单盲、平行、随机对照试验。参与者将按1:1的比例随机分配到接受为期八周的个体RT（每周30 - 45分钟）的干预组或接受标准护理的对照组。认知功能，包括简易精神状态检查表（MMSE）、波士顿命名测试（BNT）、连线测验A（TMT - A），通过患者健康问卷9项（PHQ - 9）评估的抑郁症状，以及通过卒中特异性生活质量量表（Ss - QoL）评估的生活质量，将由盲法评估者在基线（T0）、干预后（8周，T1）和4周随访（12周，T2）时进行评估。该干预采用量身定制的RT方案，允许患者选择主题（如童年记忆、工作经历）以提高参与度。盲法评估者将确保测量的客观性，并采用意向性分析处理失访问题。 讨论：本研究旨在为个体RT在改善中风患者认知功能、减轻抑郁症状和提高生活质量方面的有效性提供新的视角。基于深入的文献综述和概念分析使用量身定制的个体RT方案，以及多维评估系统，使本研究有别于以往的研究。 试验注册：本方案于2025年1月8日在中国临床试验注册中心（标识符：ChiCTR2500095471）注册。
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