Gazarian G A
Kardiologiia. 1985 Jun;25(6):24-7.
A 5% NaCl solution (500.0) was administered during 40-50 min to 20 patients with essential hypertension (10 with labile and 10 with stable hypertension) and 10 normal subjects. Total sodiuresis and diuresis values over 5 post-load hours, the timing of their peaks, and the ratio of diuresis/sodiuresis rates (d/s coefficient) were examined. In hypertensive patients, particularly those with stable hypertension, the peak of sodium excretion was displaced towards the beginning of the salt load, yet salty diuresis stopped earlier, and the total five-hour sodium excretion was significantly reduced, as compared to normal subjects. The d/s coefficient showed a less steep decline, and was generally higher, as compared to that of normal subjects at all stages of the study. The findings obtained demonstrate that 5-hour monitoring of the diuresis, sodiuresis and the d/s coefficient following a salt load can detect disorders of renal function.
向20例原发性高血压患者（10例血压不稳定者和10例血压稳定者）及10名正常受试者在40 - 50分钟内输注5%氯化钠溶液（500.0）。检测负荷后5小时的总钠利尿和利尿值、其峰值出现时间以及利尿/钠利尿速率比（d/s系数）。在高血压患者中，尤其是血压稳定的患者，钠排泄峰值向盐负荷开始时偏移，但盐利尿停止较早，与正常受试者相比，5小时总钠排泄显著减少。在研究的各个阶段，d/s系数下降不那么陡峭，且总体上高于正常受试者。所获得的结果表明，盐负荷后对利尿、钠利尿和d/s系数进行5小时监测可检测肾功能障碍。
