文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

cGAS/STING/NLRP3信号通路的研究进展：一篇综述

Research and progress of cGAS/STING/NLRP3 signaling pathway: a mini review.

作者信息

Chen Ke-Qian, Tang Wen-Rui, Liu Xiang

机构信息

Department of Clinical Pharmacy, Xiangtan Central Hospital (The Affiliated Hospital of Hunan University), Xiangtan, China.

Department of Infection Control, Xiangtan Central Hospital (The Affiliated Hospital of Hunan University), Xiangtan, China.

出版信息

Front Immunol. 2025 May 20;16:1594133. doi: 10.3389/fimmu.2025.1594133. eCollection 2025.

DOI:10.3389/fimmu.2025.1594133
PMID:40463371
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12129981/
Abstract

Over the past decade, inflammasome and cGAS-STING have received significant attention as immune components that coordinate host immune homeostasis. Although the inflammasome and cGAS-STING are relatively independent immune signaling pathways, some studies have pointed out that there is an important association between cGAS-STING and the inflammasome. As the downstream of cGAS-STING, inflammasome plays an important role in many diseases. In this mini-review, we review the association between CGAS-STING and NLRP3 inflammasome, the progression of the cGAS/STING/NLRP3 signaling pathway in the pathogenesis of disease, the therapeutic strategies that targeted cGAS/STING/NLRP3 signaling pathway. We believe that targeting the cGAS/STING/NLRP3 signaling pathway in the future has broad prospects and significance for the treatment of disease.

摘要

在过去十年中，炎性小体和cGAS-STING作为协调宿主免疫稳态的免疫成分受到了广泛关注。尽管炎性小体和cGAS-STING是相对独立的免疫信号通路，但一些研究指出cGAS-STING与炎性小体之间存在重要关联。作为cGAS-STING的下游，炎性小体在许多疾病中发挥着重要作用。在本综述中，我们回顾了CGAS-STING与NLRP3炎性小体之间的关联、cGAS/STING/NLRP3信号通路在疾病发病机制中的进展、针对cGAS/STING/NLRP3信号通路的治疗策略。我们相信，未来靶向cGAS/STING/NLRP3信号通路在疾病治疗方面具有广阔的前景和重要意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d56c/12129981/9ca72747fe97/fimmu-16-1594133-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d56c/12129981/3a7edd1183e6/fimmu-16-1594133-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d56c/12129981/0c93b425c6fb/fimmu-16-1594133-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d56c/12129981/9ca72747fe97/fimmu-16-1594133-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d56c/12129981/3a7edd1183e6/fimmu-16-1594133-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d56c/12129981/0c93b425c6fb/fimmu-16-1594133-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d56c/12129981/9ca72747fe97/fimmu-16-1594133-g003.jpg

相似文献

[1]
Research and progress of cGAS/STING/NLRP3 signaling pathway: a mini review.

Front Immunol. 2025-5-20

[2]
Cytosolic mtDNA-cGAS-STING axis contributes to sepsis-induced acute kidney injury via activating the NLRP3 inflammasome.

Clin Exp Nephrol. 2024-5

[3]
Mitochondrial (mt)DNA-cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling promotes pyroptosis of macrophages via interferon regulatory factor (IRF)7/IRF3 activation to aggravate lung injury during severe acute pancreatitis.

Cell Mol Biol Lett. 2024-4-27

[4]
Activating cGAS-STING axis contributes to neuroinflammation in CVST mouse model and induces inflammasome activation and microglia pyroptosis.

J Neuroinflammation. 2022-6-10

[5]
mtDNA-cGAS-STING axis-dependent NLRP3 inflammasome activation contributes to postoperative cognitive dysfunction induced by sevoflurane in mice.

Int J Biol Sci. 2024

[6]
Involvement of cGAS/STING Signaling in the Pathogenesis of Candida albicans Keratitis: Insights From Genetic and Pharmacological Approaches.

Invest Ophthalmol Vis Sci. 2024-6-3

[7]
cGAS/STING/NLRP3 Signaling Pathway-Mediated Pyroptosis in Hypertrophic Cardiomyopathy Radiotherapy.

Front Biosci (Landmark Ed). 2025-3-5

[8]
STING promotes NLRP3 localization in ER and facilitates NLRP3 deubiquitination to activate the inflammasome upon HSV-1 infection.

PLoS Pathog. 2020-3-18

[9]
The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3.

Cell. 2017-11-16

[10]
Hydrogen Sulfide Ameliorated High Choline-Induced Cardiac Dysfunction by Inhibiting cGAS-STING-NLRP3 Inflammasome Pathway.

Oxid Med Cell Longev. 2022-7-22

本文引用的文献

[1]
Microglial pyroptosis induced by SENP7 via the cGAS/STING/IRF3 pathway contributes to neuronal apoptosis.

Cytokine. 2025-5

[2]
CMPK2 promotes NLRP3 inflammasome activation via mtDNA-STING pathway in house dust mite-induced allergic rhinitis.

Clin Transl Med. 2025-1

[3]
Cadmium exposure triggers alveolar epithelial cell pyroptosis by inducing mitochondrial oxidative stress and activating the cGAS-STING pathway.

Cell Commun Signal. 2024-11-26

[4]
Chlamydia psittaci infection induces IFN-I and IL-1β through the cGAS-STING-IRF3/NLRP3 pathway via mitochondrial oxidative stress in human macrophages.

Vet Microbiol. 2024-12

[5]
Advances in the prerequisite and consequence of STING downstream signalosomes.

Med Rev (2021). 2024-5-8

[6]
Copper induced cytosolic escape of mitochondrial DNA and activation of cGAS-STING-NLRP3 pathway-dependent pyroptosis in C8-D1A cells.

Ecotoxicol Environ Saf. 2024-10-15

[7]
Endogenous retroviruses modulate the susceptibility of mice to Staphylococcus aureus-induced mastitis by activating cGAS-STING signaling.

Int Immunopharmacol. 2024-12-5

[8]
Double-stranded DNA enhances platelet activation, thrombosis, and myocardial injury via cyclic GMP-AMP synthase.

Cardiovasc Res. 2025-4-22

[9]
Inhibition of cGAS attenuates neonatal hypoxic-ischemic encephalopathy via regulating microglia polarization and pyroptosis.

Transl Pediatr. 2024-8-31

[10]
Disturbance of mitochondrial dynamics led to spermatogenesis disorder in mice exposed to polystyrene micro- and nanoplastics.

Environ Pollut. 2024-12-1

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索