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林奇综合征患者出现四原发性肿瘤的罕见病例。

A Rare Case of Four Primary Tumors in a Patient With Lynch Syndrome.

作者信息

Kamandi Mostafa, Layegh Negin, Disfani Hamideh Feiz

机构信息

Department of Internal Medicine, Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran.

Innovative Medical Research Center, Faculty of Medicine, Mashhad Medical Sciences Islamic Azad University Mashhad Iran.

出版信息

Clin Case Rep. 2025 Jun 2;13(6):e70560. doi: 10.1002/ccr3.70560. eCollection 2025 Jun.

DOI:10.1002/ccr3.70560
PMID:40463737
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12129822/
Abstract

This case emphasizes the complexity of LS and the need for more comprehensive surveillance strategies, particularly in those with MPTs, to enable early detection and improve management.

摘要

该病例强调了林奇综合征（LS）的复杂性以及采取更全面监测策略的必要性，尤其是对于患有黏液性息肉病（MPTs）的患者，以便能够早期发现并改善管理。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1778/12129822/bed5131d68ea/CCR3-13-e70560-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1778/12129822/bed5131d68ea/CCR3-13-e70560-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1778/12129822/bed5131d68ea/CCR3-13-e70560-g001.jpg

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A Rare Case of Four Primary Tumors in a Patient With Lynch Syndrome.林奇综合征患者出现四原发性肿瘤的罕见病例。
Clin Case Rep. 2025 Jun 2;13(6):e70560. doi: 10.1002/ccr3.70560. eCollection 2025 Jun.
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Quadruple primary tumors in a lynch syndrome patient surviving more than 26 years with genetic analysis: a case report and literature review.一名林奇综合征患者的四重原发性肿瘤，经基因分析存活超过26年：病例报告及文献综述
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本文引用的文献

1
Quadruple primary tumors in a lynch syndrome patient surviving more than 26 years with genetic analysis: a case report and literature review.一名林奇综合征患者的四重原发性肿瘤，经基因分析存活超过26年：病例报告及文献综述
Front Oncol. 2024 Jun 4;14:1382154. doi: 10.3389/fonc.2024.1382154. eCollection 2024.
2
Rare germline mutation and MSH2-&MSH6 + expression in a double primary carcinoma of colorectal carcinoma and endometrial carcinoma: a case report.罕见的种系突变和 MSH2-MSH6 表达在结直肠癌和子宫内膜癌的双原发癌中：一例报告。
Diagn Pathol. 2024 Jan 31;19(1):25. doi: 10.1186/s13000-024-01447-8.
3
PMS2-associated Lynch syndrome: Past, present and future.
与PMS2相关的林奇综合征：过去、现在与未来
Front Oncol. 2023 Feb 21;13:1127329. doi: 10.3389/fonc.2023.1127329. eCollection 2023.
4
A Focused Clinical Review of Lynch Syndrome.林奇综合征的重点临床综述
Cancer Manag Res. 2023 Jan 18;15:67-85. doi: 10.2147/CMAR.S283668. eCollection 2023.
5
Long-Term Survival of a Lynch Syndrome Patient With Eight Primary Tumors: A Case Report.一名患有8种原发性肿瘤的林奇综合征患者的长期生存：病例报告
Front Oncol. 2022 May 10;12:896024. doi: 10.3389/fonc.2022.896024. eCollection 2022.
6
Liquid Biopsy as a Source of Nucleic Acid Biomarkers in the Diagnosis and Management of Lynch Syndrome.液体活检作为林奇综合征诊断和管理中核酸生物标志物的来源。
Int J Mol Sci. 2022 Apr 13;23(8):4284. doi: 10.3390/ijms23084284.
7
Diagnostic criteria for constitutional mismatch repair deficiency (CMMRD): recommendations from the international consensus working group.遗传性错配修复缺陷（CMMRD）的诊断标准：国际共识工作组的建议。
J Med Genet. 2022 Apr;59(4):318-327. doi: 10.1136/jmedgenet-2020-107627. Epub 2021 Feb 23.
8
Genetic Counseling and Surveillance Focused on Lynch Syndrome.聚焦林奇综合征的遗传咨询与监测
J Anus Rectum Colon. 2019 Apr 25;3(2):60-68. doi: 10.23922/jarc.2019-002. eCollection 2019.
9
Multiple Primary Tumors Over a Lifetime.一生中的多发性原发性肿瘤。
Oncology (Williston Park). 2019 Jul 16;33(7):629384.
10
Recent advances in Lynch syndrome.林奇综合征的最新进展。
Fam Cancer. 2019 Apr;18(2):211-219. doi: 10.1007/s10689-018-00117-1.