Huang Chun-Feng, Ho Cheng-Jung, Lin Sung-Yen, Hwang Jawl-Shan, Tai Ta-Wei, Chen Jung-Fu, Tu Shih-Te, Chan Ding-Cheng, Yang Rong-Sen, Chen Hsuan-Yu, Tsai Keh-Sung, Cheng Tien-Tsai, Chen Fang-Ping, Hung Wei-Chieh, Chang Yin-Fan, Han Der-Sheng, Chandran Manju, Bin Ang Seng, Lee Joon Kiong, Yeap Swan Sim, Chung Yoon-Sok, Kim Kwang-Kyoun, Ebeling Peter, Jaisamrarn Unnop, Pandey Dipendra, Ferrari Serge, McCloskey Eugene, Charatcharoenwitthaya Natthinee, Taguchi Akira, Lekamwasam Sarath, Van Nguyen Tuan, Lewiecki E Michael, Saag Kenneth G, Tsai Ching-Chou, Marín Fernando, Mori Satoshi, Hwang Kyu Ri, Li-Yu Julie, Carey John J, Kendler David, Cheung Ching Lung, Huang Huei-Kai, Kuptniratsaikul Vilai, Chan Wing P, Chan Siew Pheng, Ho-Pham Lan T, Hew Fen Lee, Shi Huipeng, Reid Ian, Kanis John A, Chen Chung-Hwan, Wu Chih-Hsing
Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Department of Leisure Services Management, Chaoyang University of Technology, Taichung, Taiwan.
Osteoporos Int. 2025 Jun 4. doi: 10.1007/s00198-025-07559-1.
Osteoporosis in men is an underdiagnosed and undertreated condition that leads to significant morbidity and mortality, particularly in the aging population. This consensus report provides tailored guidelines for diagnosing, preventing, and treating male osteoporosis in the Asia-Pacific region by integrating global best practices with regional adaptations.
To establish evidence-based, region-specific guidelines for the management of male osteoporosis in the Asia-Pacific region, addressing demographic and lifestyle factors.
Expert feedback was gathered through premeeting reviews, consensus conferences, and collaborative discussions. A life-course approach was employed to align international best practices with Asia-Pacific-specific needs, emphasizing continuous monitoring and intervention from middle age onward.
The 12 consensus strategies systematically approach male osteoporosis management, addressing screening, diagnosis, treatment, and long-term follow-up. Recommendations include the assessment of fracture risk for men aged 50 years and above, use of dual-energy X-ray absorptiometry (DXA) testing for men aged 70 years and above, lifestyle modifications, and pharmacological interventions such as bisphosphonates, denosumab, and anabolic agents for high-risk patients. Secondary causes of osteoporosis were highlighted, along with the establishment of fracture liaison services (FLSs) to improve long-term care. A life-course approach was proposed to optimize bone health throughout men's lives.
This consensus provides a comprehensive framework tailored to the Asia-Pacific region for diagnosing, preventing, and managing osteoporosis in men. By addressing region-specific challenges and promoting evidence-based interventions, the latest guidelines incorporating the consensus may depict the conceptual direction in reducing fracture risk and improving long-term bone health outcomes for osteoporosis in men.
男性骨质疏松症是一种诊断不足且治疗不足的疾病，会导致显著的发病率和死亡率，在老年人群体中尤为如此。本共识报告通过将全球最佳实践与区域适应性相结合，为亚太地区男性骨质疏松症的诊断、预防和治疗提供了量身定制的指南。
制定基于证据的、针对亚太地区男性骨质疏松症管理的特定区域指南，同时考虑人口统计学和生活方式因素。
通过会前评审、共识会议和协作讨论收集专家反馈。采用生命历程方法，使国际最佳实践与亚太地区的特定需求保持一致，强调从中年开始进行持续监测和干预。
这12项共识策略系统地探讨了男性骨质疏松症的管理，涉及筛查、诊断、治疗和长期随访。建议包括评估50岁及以上男性的骨折风险，对70岁及以上男性使用双能X线吸收法（DXA）检测，改变生活方式，以及对高危患者采用双膦酸盐、地诺单抗和促合成代谢药物等药物干预措施。强调了骨质疏松症的继发性病因，以及建立骨折联络服务（FLS）以改善长期护理。提出了一种生命历程方法，以在男性的一生中优化骨骼健康。
本共识为亚太地区男性骨质疏松症的诊断、预防和管理提供了一个量身定制的综合框架。通过应对特定区域的挑战并推广基于证据的干预措施，纳入该共识的最新指南可能描绘出降低男性骨质疏松症骨折风险和改善长期骨骼健康结局的概念方向。
