用于痴呆症诊断中个性化医疗的基于生物流体的生物标志物组合
Biofluid-based biomarker panels toward personalized medicine in dementia diagnostics.
作者信息
Zetterberg Henrik
机构信息
Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
出版信息
Alzheimers Dement. 2025 Jun;21(6):e70178. doi: 10.1002/alz.70178.
Abstract
Alzheimer's & Dementia publishes a set of papers exploring the diagnostic and prognostic capabilities of a novel cutting-edge multiplexed biomarker measurement technology across neurodegenerative dementias.
摘要
《阿尔茨海默病与痴呆症》发表了一组论文，探讨了一种新型前沿多重生物标志物测量技术在神经退行性痴呆症中的诊断和预后能力。
相似文献
1
Biofluid-based biomarker panels toward personalized medicine in dementia diagnostics.用于痴呆症诊断中个性化医疗的基于生物流体的生物标志物组合
Alzheimers Dement. 2025 Jun;21(6):e70178. doi: 10.1002/alz.70178.
2
CSF tau and the CSF tau/ABeta ratio for the diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment (MCI).脑脊液tau蛋白及脑脊液tau蛋白与β淀粉样蛋白比值在轻度认知障碍（MCI）患者中用于诊断阿尔茨海默病性痴呆及其他痴呆。
Cochrane Database Syst Rev. 2017 Mar 22;3(3):CD010803. doi: 10.1002/14651858.CD010803.pub2.
3
Mini-Cog for the diagnosis of Alzheimer's disease dementia and other dementias within a primary care setting.在初级保健机构中用于诊断阿尔茨海默病性痴呆及其他痴呆的简易认知评估工具。
Cochrane Database Syst Rev. 2018 Feb 22;2(2):CD011415. doi: 10.1002/14651858.CD011415.pub2.
4
18F PET with flutemetamol for the early diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment (MCI).使用氟代甲磺酸去甲肾上腺素的18F正电子发射断层显像用于轻度认知障碍（MCI）患者中阿尔茨海默病性痴呆及其他痴呆的早期诊断。
Cochrane Database Syst Rev. 2017 Nov 22;11(11):CD012884. doi: 10.1002/14651858.CD012884.
5
18F PET with florbetapir for the early diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment (MCI).使用氟代硼吡咯进行18F正电子发射断层显像以早期诊断轻度认知障碍（MCI）患者的阿尔茨海默病性痴呆及其他痴呆。
Cochrane Database Syst Rev. 2017 Nov 22;11(11):CD012216. doi: 10.1002/14651858.CD012216.pub2.
6
Independent validation and outlier analysis of EuroPOND alzheimer's disease staging model using ADNI and real-world clinical data.使用阿尔茨海默病神经影像学倡议（ADNI）和真实世界临床数据对欧洲阿尔茨海默病分期模型进行独立验证和异常值分析。
Alzheimers Res Ther. 2025 Jun 16;17(1):134. doi: 10.1186/s13195-025-01788-6.
7
7T MRI for neurodegenerative dementias in vivo: a systematic review of the literature.7T MRI 用于神经退行性痴呆的活体研究：文献系统综述。
J Neurol Neurosurg Psychiatry. 2017 Jul;88(7):564-574. doi: 10.1136/jnnp-2016-315022. Epub 2017 Mar 4.
8
Biomarkers in Alzheimer's disease: new frontiers with olfactory models.阿尔茨海默病中的生物标志物：嗅觉模型的新前沿
Inflammopharmacology. 2025 May 1. doi: 10.1007/s10787-025-01705-1.
9
Plasma and cerebrospinal fluid amyloid beta for the diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment (MCI).血浆和脑脊液β淀粉样蛋白用于诊断轻度认知障碍（MCI）患者的阿尔茨海默病性痴呆及其他痴呆。
Cochrane Database Syst Rev. 2014 Jun 10;2014(6):CD008782. doi: 10.1002/14651858.CD008782.pub4.
10
Two-Year Prognostic Utility of Plasma p217+tau across the Alzheimer's Continuum.血浆p217 + tau在阿尔茨海默病连续体中的两年预后效用
J Prev Alzheimers Dis. 2023;10(4):828-836. doi: 10.14283/jpad.2023.83.
本文引用的文献
1
The Alzheimer's Association Global Biomarker Standardization Consortium (GBSC) plasma phospho-tau Round Robin study.阿尔茨海默病协会全球生物标志物标准化联盟（GBSC）血浆磷酸化tau蛋白循环检验研究。
Alzheimers Dement. 2025 Feb;21(2):e14508. doi: 10.1002/alz.14508. Epub 2025 Feb 5.
2
Recommendations for clinical implementation of blood-based biomarkers for Alzheimer's disease.用于阿尔茨海默病的基于血液的生物标志物的临床实施建议。
Alzheimers Dement. 2024 Nov;20(11):8216-8224. doi: 10.1002/alz.14184. Epub 2024 Oct 1.
3
NULISA: a proteomic liquid biopsy platform with attomolar sensitivity and high multiplexing.NULISA：一种具有阿伏伽德罗灵敏度和高多重检测能力的蛋白质组学液体活检平台。
Nat Commun. 2023 Nov 9;14(1):7238. doi: 10.1038/s41467-023-42834-x.
4
Methods to Discover and Validate Biofluid-Based Biomarkers in Neurodegenerative Dementias.发现和验证神经退行性痴呆症生物体液生物标志物的方法。
Mol Cell Proteomics. 2023 Oct;22(10):100629. doi: 10.1016/j.mcpro.2023.100629. Epub 2023 Aug 7.
5
Hallmarks of neurodegenerative diseases.神经退行性疾病的特征。
Cell. 2023 Feb 16;186(4):693-714. doi: 10.1016/j.cell.2022.12.032.
6
Single-molecule enzyme-linked immunosorbent assay detects serum proteins at subfemtomolar concentrations.单分子酶联免疫吸附测定法可检测纳飞摩尔浓度级别的血清蛋白。
Nat Biotechnol. 2010 Jun;28(6):595-9. doi: 10.1038/nbt.1641. Epub 2010 May 23.
Zotero 插件