Westhofen M, Herberhold C, Thayssen G, Jend H H
Laryngol Rhinol Otol (Stuttg). 1985 Aug;64(8):378-87.
This is the first report to be published on olfactory evoked potentials in patients with well-defined lesions of the central nervous system and the trigeminal nerve. Absence of olfactory evoked potentials is seen in post-central and parietotemporal lesions. The first peak of the so-called olfactory evoked twin potential is absent in lesions of the basal nuclei and sectioning of the trigeminal or ophthalmic nerve, whereas there is no second peak in subcortico-frontal and cortico-temporal lesions. Tumours of the corpus callosum and sectioning of the maxillary and mandibular nerves do not disturb the olfactory evoked potentials. The anatomically different localisation and the functional synergism of the olfactory and trigeminal systems in the perception of odours and the processing of olfactory evoked potentials are pointed out.
这是首篇发表的关于中枢神经系统和三叉神经有明确病变患者嗅觉诱发电位的报告。中央后回及顶颞叶病变时可出现嗅觉诱发电位缺失。基底核病变以及三叉神经或眼神经切断时，所谓嗅觉诱发双峰电位的第一个峰消失，而皮质下额叶及颞叶皮质病变时则无第二个峰。胼胝体肿瘤以及上颌神经和下颌神经切断并不干扰嗅觉诱发电位。文中指出了嗅觉和三叉神经系统在气味感知及嗅觉诱发电位处理过程中解剖学上不同的定位及功能协同作用。
