Lewin Antoine, Goldman Mindy, O'Brien Sheila F, Irving David O, Vassallo Ralph, Tiberghien Pierre, Goto Naoko, Waters Allison, van de Laar Thijs, Jacquot Cyril, Fachini Roberta, Germain Marc
Medical Affairs and Innovation, Héma-Québec, Montreal, Quebec, Canada.
Donation Policy and Studies, Canadian Blood Services, Ottawa, Ontario, Canada.
Vox Sang. 2025 Aug;120(8):776-783. doi: 10.1111/vox.70055. Epub 2025 Jun 4.
Early in the COVID-19 pandemic, blood suppliers faced unique challenges meeting changing demand while maintaining safety for donors, recipients and staff. Actions taken may have altered the composition of the donor base and the frequency of confirmed-positive infectious disease marker (IDM) rates. No studies have evaluated the impact of the pandemic on donations, donor demographics and blood safety across several countries.
Whole blood/red blood cell (RBC) donors and donations and confirmed IDM reactivity recorded during from 11 March 2019 to 11 September 2019 ("pre-pandemic period") and from 11 March 2020 to 11 September 2020 ("pandemic period") were collected by 11 blood services participating in the Biomedical Excellence for Safer Transfusion (BEST) Collaborative.
Eleven blood services from nine countries reported on over 4 million donations per period. On average, donations dropped by 4.0% between pre-pandemic and pandemic periods, driven by fewer donations from active repeat donors (-5.6%) and first-time [FT] donors (-14.0%) but partially offset by more donations from lapsed donors (+15.7%). The decline was also driven by fewer donations from male donors (-7.6%) and younger donors (i.e., 16-25 years: -19.0%). Overall, the rate of confirmed IDM positivity dropped from 100.0 to 88.6 per 100,000 donors (-11.4%) between pre-pandemic and pandemic periods.
Early in the pandemic, blood donations, particularly from FT donors, decreased. In future respiratory virus pandemics, blood banks should anticipate changes in demand, collection site locations and capacity and donor behaviour. Unlike results in acute catastrophes, lower rates of confirmed IDM positivity were observed, in part related to lower numbers of FT, male and younger donors.
在新型冠状病毒肺炎疫情初期，血液供应机构在满足不断变化的需求同时，还要确保捐赠者、受血者和工作人员的安全，面临着独特的挑战。采取的措施可能改变了献血者群体的构成以及确诊阳性传染病标志物（IDM）率的出现频率。尚无研究评估疫情对多个国家献血、献血者人口统计学特征和血液安全的影响。
参与“更安全输血生物医学卓越计划”（BEST）协作项目的11家血液服务机构收集了2019年3月11日至2019年9月11日（“疫情前时期”）以及2020年3月11日至2020年9月11日（“疫情时期”）期间全血/红细胞（RBC）献血者、献血情况以及确诊的IDM反应性记录。
来自9个国家的11家血液服务机构报告了每个时期超过400万次的献血情况。平均而言，疫情前时期到疫情时期献血量下降了4.0%，主要是由于活跃的重复献血者（-5.6%）和首次献血者（FT，-14.0%）的献血量减少，但部分被既往未献血者增加的献血量（+15.7%）所抵消。献血量下降还归因于男性献血者（-7.6%）和年轻献血者（即16 - 25岁：-19.0%）的献血量减少。总体而言，疫情前时期到疫情时期确诊的IDM阳性率从每10万名献血者100.0降至88.6（-11.4%）。
在疫情初期，献血量有所下降，尤其是首次献血者的献血量。在未来的呼吸道病毒疫情中，血库应预计需求、采血地点和能力以及献血者行为的变化。与急性灾难的结果不同，确诊的IDM阳性率较低，部分原因是首次献血者、男性和年轻献血者数量减少。
