Brogard J M, Pinget M, Dorner M, Blickle J F
Liver. 1985 Jun;5(3):147-55. doi: 10.1111/j.1600-0676.1985.tb00230.x.
Biliary elimination of 15 beta-lactams was studied using a model of isolated perfused rabbit liver. During the perfusion period, the main liver functions were well preserved. The highest biliary concentrations were reached by antibiotics of the penicillin group, and the highest biliary recovery was observed with metampicillin, apalcillin and mezlocillin (46.5, 30.7 and 20.3%, respectively, of the dose administered). This technique was also suitable for estimating the degree of bio-transformation in the liver of the antibiotics studied.
使用离体灌注兔肝模型研究了15种β-内酰胺类药物的胆汁排泄情况。在灌注期间，肝脏的主要功能得到了良好的维持。青霉素类抗生素的胆汁浓度最高，美坦西林、阿帕西林和 mezlocillin 的胆汁回收率最高（分别为给药剂量的46.5%、30.7%和20.3%）。该技术也适用于评估所研究抗生素在肝脏中的生物转化程度。
