Che Ping, Cai Li, Liu Fang, Wang Yidi, Zhang Yanxin, Wang Ying, Lu Qingzheng, Piao Zhiyan, Zhang Xiaoyi, Qin Wen, Zhang Nan
Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China.
PET/CT Center, Tianjin Medical University General Hospital, Tianjin, China.
Transl Psychiatry. 2025 Jun 4;15(1):189. doi: 10.1038/s41398-025-03402-7.
Cerebral blood flow (CBF) changes play a pivotal role in the pathogenesis and progression of Alzheimer's disease (AD), but their effects on other pathological processes, such as neurodegeneration and amyloid-β deposition, are unclear. We investigated the correlations between cerebral perfusion measured with arterial spinal labeling (ASL) and cerebral metabolism and amyloid deposition on positron emission tomography (PET) scans in AD. Sixty-four AD patients and 56 cognitively unimpaired controls were included. Cerebral perfusion was indicated by the expression of AD-related perfusion pattern (ADRP), global CBF and the relative value of regional CBF. The standardized uptake value ratio (SUVR) of regions of interest (ROIs) was calculated for F-fluorodeoxyglucose (FDG)-PET and C-Pittsburgh Compound B (PiB)-PET images in AD patients. The subject expression score of ADRP showed strong negative correlations with FDG SUVR in all ROIs and a positive correlation with PiB SUVR in temporal. FDG SUVR in some ROIs were also positively correlated with global CBF and relatively regional CBF in the temporoparietal cortex, precuneus and posterior cingulate, and negatively correlated with relatively regional CBF in the thalamus and pre- and postcentral regions. The PiB SUVR of the ROIs were negatively correlated with the relatively regional CBF in the left inferior parietal region and were positively correlated with the relatively regional CBF in the right thalamus and left precentral regions. CBF was significantly correlated with hypometabolism and amyloid deposition in AD.
脑血流量（CBF）变化在阿尔茨海默病（AD）的发病机制和进展中起关键作用，但其对其他病理过程（如神经退行性变和淀粉样β蛋白沉积）的影响尚不清楚。我们研究了动脉自旋标记（ASL）测量的脑灌注与AD患者正电子发射断层扫描（PET）上的脑代谢和淀粉样蛋白沉积之间的相关性。纳入了64例AD患者和56例认知未受损的对照者。通过AD相关灌注模式（ADRP）的表达、全脑CBF和局部CBF的相对值来表示脑灌注。计算了AD患者F-氟脱氧葡萄糖（FDG）-PET和C-匹兹堡化合物B（PiB）-PET图像上感兴趣区域（ROI）的标准化摄取值比率（SUVR）。ADRP的受试者表达评分在所有ROI中与FDG SUVR呈强负相关，在颞叶与PiB SUVR呈正相关。部分ROI中的FDG SUVR在颞顶叶皮质、楔前叶和后扣带回也与全脑CBF和相对局部CBF呈正相关，而在丘脑以及中央前回和中央后回与相对局部CBF呈负相关。ROI的PiB SUVR在左侧顶下叶区域与相对局部CBF呈负相关，在右侧丘脑和左侧中央前回与相对局部CBF呈正相关。CBF与AD中的代谢减退和淀粉样蛋白沉积显著相关。
