应用于BioFIND队列中已确诊帕金森病的新诊断和分期框架。

New diagnostic and staging framework applied to established PD in the BioFIND cohort.

作者信息

Russo Marco J, Kang Un Jung

机构信息

Movement Disorders Division, Department of Neurology, Rutgers University, Robert Wood Johnson Medical School, New Brunswick, NJ, USA.

The Marlene and Paolo Fresco Institute for Parkinson's & Movement Disorders, Department of Neurology, Department of Neuroscience and Physiology, Neuroscience Institute, The Parekh Center for Interdisciplinary Neurology, NYU Grossman School of Medicine, New York, NY, USA.

出版信息

NPJ Parkinsons Dis. 2025 Jun 4;11(1):151. doi: 10.1038/s41531-025-00992-3.

DOI:10.1038/s41531-025-00992-3

PMID:40467579

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12137746/

Abstract

The proposed Neuronal α-Synuclein Disease Integrated Staging System (NSD-ISS) was recently applied to early Parkinson's disease (PD) cohorts. We applied this research framework to the BioFIND study cohort, which includes more moderately advanced PD participants with clinically established PD. Disease durations within each ISS stage were highly variable. Cognitive and non-motor anchors had little weight in determining staging. The analysis highlights strengths and limitations of NSD-ISS to guide further refinement of an integrated staging system.

摘要

最近，所提出的神经元α-突触核蛋白病综合分期系统（NSD-ISS）被应用于早期帕金森病（PD）队列。我们将这个研究框架应用于BioFIND研究队列，该队列包括更多临床确诊的中度进展期PD参与者。每个ISS阶段内的病程差异很大。认知和非运动指标在确定分期时权重较小。该分析突出了NSD-ISS的优势和局限性，以指导综合分期系统的进一步完善。