Russo Marco J, Kang Un Jung
Movement Disorders Division, Department of Neurology, Rutgers University, Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
The Marlene and Paolo Fresco Institute for Parkinson's & Movement Disorders, Department of Neurology, Department of Neuroscience and Physiology, Neuroscience Institute, The Parekh Center for Interdisciplinary Neurology, NYU Grossman School of Medicine, New York, NY, USA.
NPJ Parkinsons Dis. 2025 Jun 4;11(1):151. doi: 10.1038/s41531-025-00992-3.
The proposed Neuronal α-Synuclein Disease Integrated Staging System (NSD-ISS) was recently applied to early Parkinson's disease (PD) cohorts. We applied this research framework to the BioFIND study cohort, which includes more moderately advanced PD participants with clinically established PD. Disease durations within each ISS stage were highly variable. Cognitive and non-motor anchors had little weight in determining staging. The analysis highlights strengths and limitations of NSD-ISS to guide further refinement of an integrated staging system.
最近，所提出的神经元α-突触核蛋白病综合分期系统（NSD-ISS）被应用于早期帕金森病（PD）队列。我们将这个研究框架应用于BioFIND研究队列，该队列包括更多临床确诊的中度进展期PD参与者。每个ISS阶段内的病程差异很大。认知和非运动指标在确定分期时权重较小。该分析突出了NSD-ISS的优势和局限性，以指导综合分期系统的进一步完善。
