Yavuzyigitoglu Serdar, Sabazade Shiva, Gill Viktor, Brosens Erwin, Kiliç Emine, Stålhammar Gustav
Department of Ophthalmology, Erasmus MC Cancer Institute, Erasmus MC, Rotterdam, The Netherlands.
Division of Eye and Vision, Department of Clinical Neuroscience, Karolinska Institutet, Eugeniavägen 12, 17164, Stockholm, Sweden.
Sci Rep. 2025 Jun 4;15(1):19557. doi: 10.1038/s41598-025-03961-1.
In this international collaboration, we examined whether survival in metastatic uveal melanoma is associated with primary tumor size at initial diagnosis. A total of 128 and 205 patients with American Joint Committee on Cancer (AJCC) stage IV disease were included from the Netherlands and Sweden, respectively. Across both cohorts, patients whose tumors had a largest basal diameter ≥ 16 mm or a higher AJCC stage presented with a greater number of hepatic metastases and showed shorter Kaplan-Meier overall survival from the time of metastatic detection. However, this association did not persist after adjustment for the number of hepatic metastases in multivariate Cox regression and a Markov multi-state model. These findings suggest that primary tumor size is associated with survival in metastatic disease and the burden of metastatic lesions at detection, indicating a potential survival benefit of primary tumor treatment. Nevertheless, caution is warranted when interpreting these results, as they differ from some previous reports.
在这项国际合作研究中，我们探究了转移性葡萄膜黑色素瘤患者的生存率是否与初次诊断时的原发性肿瘤大小相关。分别从荷兰和瑞典纳入了128例和205例美国癌症联合委员会（AJCC）IV期疾病患者。在两个队列中，肿瘤最大基底直径≥16 mm或AJCC分期更高的患者出现的肝转移数量更多，并且从转移检测时起的Kaplan-Meier总生存期更短。然而，在多变量Cox回归和马尔可夫多状态模型中对肝转移数量进行校正后，这种关联不再存在。这些发现表明，原发性肿瘤大小与转移性疾病的生存率以及检测时转移灶的负担相关，提示原发性肿瘤治疗可能具有生存获益。尽管如此，在解释这些结果时仍需谨慎，因为它们与之前的一些报告不同。
