Geethika Rayapati, Mounika Valluri, Mohamed Afroze Sultana, Menavath Tulasi Ram Naik, Puttagunta Srinivasa Babu, Yalavarthy Karthik C, Jada Naga Lakshmi
Jawaharlal Nehru Technological University, Kakinada, Kakinada, India.
Eur J Orthop Surg Traumatol. 2025 Jun 4;35(1):234. doi: 10.1007/s00590-025-04345-x.
Pain is the major concern of human kind since our beginning, and it has been the object of ubiquitous efforts to understand and control it. To reliving and prevent the pain sensation during surgeries, anaesthesia is widely used. It also reliving postoperative analgesia and improves the quality of life of patient as result in fast recovery and hence reduction in the medication cost for treatment. Current study is to compare the analgesic effect of dexmedetomidine and magnesium sulphate as adjuvants to bupivacaine and lignocaine for adductor canal block for postoperative analgesia in Total Knee Replacement patients.
We collected 50 cases prospectively, as per criteria of American society of Anaesthesiology I & American Society of Anaesthesiology II both men and women undergoing lower limb surgeries Total Knee Replacement over a period of 3 months in the department of anaesthesiology, collecting informed consent form, patients randomly allocated to one of the two groups-Group A & Group B.
Onset of block, duration of block was compared in two groups along with vital parameters. We found that administration of bupivacaine with dexmedetomidine shows rapid onset of action & prolonged duration of action when compared to the patients treated with bupivacaine with magnesium sulphate. Both the combinations show similar haemodynamic stability however slight variations were observed.
自人类诞生以来，疼痛一直是人类主要关注的问题，并且一直是人们为理解和控制它而普遍努力的对象。为了在手术期间减轻和预防疼痛感觉，麻醉被广泛使用。它还能减轻术后疼痛，并由于恢复快从而降低治疗用药成本，进而提高患者的生活质量。当前的研究旨在比较右美托咪定和硫酸镁作为布比卡因和利多卡因辅助药物用于全膝关节置换患者内收肌管阻滞术后镇痛的镇痛效果。
我们前瞻性地收集了50例患者，按照美国麻醉医师协会I级和美国麻醉医师协会II级标准，在麻醉科3个月的时间里纳入了接受下肢手术全膝关节置换的男性和女性患者，收集知情同意书，患者被随机分配到两组之一——A组和B组。
比较了两组的阻滞起效时间、阻滞持续时间以及生命体征参数。我们发现，与使用布比卡因加硫酸镁治疗的患者相比，使用布比卡因加右美托咪定的患者起效迅速且作用持续时间延长。两种组合均显示出相似的血流动力学稳定性，不过也观察到了细微差异。
