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Stress granules shape metabolic reprogramming and drug resistance.

作者信息

Zhong Shanshan, Yin Huiyong

机构信息

Department of Biomedical Sciences, Jockey Club College of Veterinary Medicine and Life Sciences, Tung Biomedical Science Center, City University of Hong Kong, Hong Kong, China.

出版信息

Nat Cancer. 2025 Jun 4. doi: 10.1038/s43018-024-00886-y.

DOI:10.1038/s43018-024-00886-y
PMID:40467994
Abstract
摘要

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Stress granules shape metabolic reprogramming and drug resistance.应激颗粒塑造代谢重编程和耐药性。
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2
RIOK1 phase separation restricts PTEN translation via stress granules activating tumor growth in hepatocellular carcinoma.RIOK1相分离通过应激颗粒限制PTEN翻译，从而激活肝细胞癌中的肿瘤生长。
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本文引用的文献

1
RIOK1 phase separation restricts PTEN translation via stress granules activating tumor growth in hepatocellular carcinoma.RIOK1相分离通过应激颗粒限制PTEN翻译，从而激活肝细胞癌中的肿瘤生长。
Nat Cancer. 2025 Jun 4. doi: 10.1038/s43018-025-00984-5.
2
CHD1 loss reprograms SREBP2-driven cholesterol synthesis to fuel androgen-responsive growth and castration resistance in SPOP-mutated prostate tumors.CHD1缺失可重编程由SREBP2驱动的胆固醇合成，为SPOP突变的前列腺肿瘤中雄激素反应性生长和去势抵抗提供能量。
Nat Cancer. 2025 May 13. doi: 10.1038/s43018-025-00952-z.
3
Time-resolved proteomic profiling reveals compositional and functional transitions across the stress granule life cycle.
时间分辨蛋白质组学分析揭示应激颗粒生命周期中组成和功能的转变。
Nat Commun. 2023 Nov 27;14(1):7782. doi: 10.1038/s41467-023-43470-1.
4
Stress granules offer first aid for leaky organelles.应激颗粒为受损细胞器提供急救。
Nature. 2023 Nov;623(7989):919-920. doi: 10.1038/d41586-023-03417-4.
5
Stress granules and hormetic adaptation of cancer.应激颗粒与癌症的应激适应
Trends Cancer. 2023 Dec;9(12):995-1005. doi: 10.1016/j.trecan.2023.08.005. Epub 2023 Sep 11.
6
The pentose phosphate pathway in health and disease.戊糖磷酸途径与健康和疾病。
Nat Metab. 2023 Aug;5(8):1275-1289. doi: 10.1038/s42255-023-00863-2. Epub 2023 Aug 23.
7
Cytosolic aldose metabolism contributes to progression from cirrhosis to hepatocarcinogenesis.细胞质醛糖代谢促进肝硬化向肝癌发生的进展。
Nat Metab. 2023 Jan;5(1):41-60. doi: 10.1038/s42255-022-00711-9. Epub 2023 Jan 19.
8
Evolving therapeutic landscape of advanced hepatocellular carcinoma.晚期肝细胞癌不断演变的治疗格局。
Nat Rev Gastroenterol Hepatol. 2023 Apr;20(4):203-222. doi: 10.1038/s41575-022-00704-9. Epub 2022 Nov 11.
9
Aldolase B suppresses hepatocellular carcinogenesis by inhibiting G6PD and pentose phosphate pathways.醛缩酶B通过抑制葡萄糖-6-磷酸脱氢酶（G6PD）和磷酸戊糖途径来抑制肝细胞癌发生。
Nat Cancer. 2020 Jul;1(7):735-747. doi: 10.1038/s43018-020-0086-7. Epub 2020 Jul 6.
10
Stress granules inhibit fatty acid oxidation by modulating mitochondrial permeability.应激颗粒通过调节线粒体通透性来抑制脂肪酸氧化。
Cell Rep. 2021 Jun 15;35(11):109237. doi: 10.1016/j.celrep.2021.109237.