癌症和免疫细胞中的Y染色体丢失可能会使治疗结果恶化。 - Suppr

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Y-chromosome loss in cancer and immune cells might worsen treatment outcomes.

作者信息

McGranahan Nicholas, Roychoudhuri Rahul

出版信息

Nature. 2025 Jun;642(8069):873-875. doi: 10.1038/d41586-025-01450-z.

DOI:10.1038/d41586-025-01450-z

PMID:40468105

Abstract

摘要

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本文引用的文献

Y chromosome loss in cancer drives growth by evasion of adaptive immunity.Y 染色体缺失可通过逃避适应性免疫促进肿瘤生长。

Nature. 2023 Jul;619(7970):624-631. doi: 10.1038/s41586-023-06234-x. Epub 2023 Jun 21.

Sex-based differences in response to anti-PD-1 or PD-L1 treatment in patients with non-small-cell lung cancer expressing high PD-L1 levels. A systematic review and meta-analysis of randomized clinical trials.高 PD-L1 表达的非小细胞肺癌患者抗 PD-1 或 PD-L1 治疗的性别差异：随机临床试验的系统评价和荟萃分析。

ESMO Open. 2021 Oct;6(5):100251. doi: 10.1016/j.esmoop.2021.100251. Epub 2021 Aug 26.

Predictors of mosaic chromosome Y loss and associations with mortality in the UK Biobank.Y 染色体嵌合体丢失的预测因子及其与英国生物库死亡率的相关性。

Sci Rep. 2018 Aug 17;8(1):12316. doi: 10.1038/s41598-018-30759-1.

Mosaic Loss of Chromosome Y in Blood Is Associated with Alzheimer Disease.血液中Y染色体的嵌合缺失与阿尔茨海默病相关。

Am J Hum Genet. 2016 Jun 2;98(6):1208-1219. doi: 10.1016/j.ajhg.2016.05.014. Epub 2016 May 23.

Mutagenesis. Smoking is associated with mosaic loss of chromosome Y.诱变作用。吸烟与Y染色体的嵌合性缺失有关。

Science. 2015 Jan 2;347(6217):81-3. doi: 10.1126/science.1262092. Epub 2014 Dec 4.

Mosaic loss of chromosome Y in peripheral blood is associated with shorter survival and higher risk of cancer.外周血中Y染色体的嵌合性缺失与较短的生存期及较高的癌症风险相关。

Nat Genet. 2014 Jun;46(6):624-8. doi: 10.1038/ng.2966. Epub 2014 Apr 28.

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