• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

单次就诊全口非手术治疗对长期牙周治疗效果的影响及危险因素分析:一项回顾性研究

Effect of single-visit full-mouth non-surgical therapy and risk factor analysis on long-term periodontal treatment outcomes: aretrospective study.

作者信息

Mandil Obada, Alrmali Abdusalam, Kalani Khushboo, Ray Bidisha, Ghataliya Parth, Alhazmi Shahad, Levine Robert A, Saleh Muhammad H A, Wang Hom-Lay

机构信息

Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI, USA.

Department of Periodontics, School of Dental Medicine, Case Western Reserve University, Cleveland, OH, USA.

出版信息

Clin Oral Investig. 2025 Jun 5;29(6):333. doi: 10.1007/s00784-025-06405-2.

DOI:10.1007/s00784-025-06405-2
PMID:40468146
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12137392/
Abstract

OBJECTIVES

This study aimed to evaluate the long-term effectiveness of single-visit full-mouth non-surgical therapy in managing patients with progressive periodontitis during supportive periodontal therapy (SPT), with tooth loss due to periodontitis (TLP) as the primary outcome. Secondary objectives included assessing changes in probing depth (PD) and identifying risk factors associated with TLP.

MATERIALS AND METHODS

A retrospective analysis was conducted using patient records from the University of Michigan School of Dentistry. Included were 283 patients (mean age: 53.2 years) with periodontal breakdown during SPT (PiKS) who underwent single-visit full-mouth ultrasonic instrumentation. The primary outcome was TLP over a mean follow-up of 19.4 years. Secondary outcomes included changes in PD (≥ 5 mm and ≥ 6 mm) and identification of risk factors for tooth loss. Statistical analyses used multilevel binary logistic regression with generalized estimating equations (GEE) and linear regression models.

RESULTS

Among 283 patients (mean age: 53.2 years), the mean TLP was 0.9 teeth per patient over a mean follow-up of 19.4 years. Factors significantly associated with TLP included diabetes (OR = 2.41; p = 0.013), current smoking (OR = 2.13; p = 0.025), higher periodontitis Grades B and C (OR = 3.31; p = 0.001), and Stages III-IV (OR = 8.67; p = 0.001). Baseline pocket depths (PD) ≥ 5 mm (OR = 1.13; p = 0.002) and ≥ 6 mm (OR = 1.29; p = 0.001) were also associated with higher TLP. Each additional annual SPT visit reduced the TLP risk by half (OR = 0.50; p = 0.003). PD ≥ 5 mm showed minimal increase change (0.16; p = 0.02), while depths ≥ 6 mm actually decreased (-0.10; p = 0.01).

CONCLUSION

Single-visit full-mouth non-surgical therapy is effective for long-term management of PiKS, with low tooth loss rates. Diabetes, smoking, advanced periodontitis stage/grade, and deeper baseline pockets are key predictors of TLP. Frequent SPT visits significantly mitigate tooth loss risk.

CLINICAL RELEVANCE

During (SPT) appointments, prevalent practice involves the full-mouth instrumentation of persistent periodontal pockets to disrupt microbial populations and consequently reduce the inflammatory response responsible for disease progression. This study investigates the efficacy of single-visit full-mouth instrumentation as a potential alternative to standard practices in controlling periodontal disease during SPT, which have potential benefits for patients, including reduced treatment time, improved adherence to maintenance therapy, and comprehensive management of periodontal disease. By minimizing the number of visits, this approach may enhance patient compliance while reducing the risk of reinfection from untreated sites between sessions, ultimately contributing to better long-term periodontal stability. Factors such as deeper baseline probing depths and crucial risk elements for TLP-including diabetes, smoking, and advanced stages (III-IV) and grades (B and C) of periodontitis, can play a role in TLP. Additionally, this study provides valuable insights into the customization of more intensive interventions for patients at higher risk. Our findings highlight the importance of frequent SPT visits, with each additional annual visit halving the risk of TLP. The observed reduction in PD of ≥ 6 mm following treatment indicates the significant potential of comprehensive debridement for enhancing long-term periodontal stability. This evidence supports the implementation of tailored, intensive SPT schedules, particularly for patients identified as having higher risks, thereby contributing to improved clinical outcomes in periodontal disease management.

摘要

目的

本研究旨在评估单次全口非手术治疗在支持性牙周治疗(SPT)期间对进展期牙周炎患者的长期疗效,以牙周炎导致的牙齿丧失(TLP)作为主要结局。次要目标包括评估探诊深度(PD)的变化以及确定与TLP相关的危险因素。

材料与方法

使用密歇根大学牙科学院的患者记录进行回顾性分析。纳入283例在SPT期间出现牙周破坏(PiKS)且接受单次全口超声洁治的患者(平均年龄:53.2岁)。主要结局是在平均19.4年的随访期内的TLP。次要结局包括PD(≥5mm和≥6mm)的变化以及牙齿丧失危险因素的识别。统计分析采用广义估计方程(GEE)的多水平二元逻辑回归和线性回归模型。

结果

在283例患者(平均年龄:53.2岁)中,平均随访19.4年期间,每位患者的平均TLP为0.9颗牙。与TLP显著相关的因素包括糖尿病(OR = 2.41;p = 0.013)、当前吸烟(OR = 2.13;p = 0.025)、牙周炎B级和C级较高(OR = 3.31;p = 0.001)以及III-IV期(OR = 8.67;p = 0.001)。基线袋深度(PD)≥5mm(OR = 1.13;p = 0.002)和≥6mm(OR = 1.29;p = 0.001)也与较高的TLP相关。每年额外进行一次SPT就诊可使TLP风险降低一半(OR = 0.50;p = 0.003)。PD≥5mm显示出最小的增加变化(0.16;p = 0.02),而深度≥6mm实际上有所下降(-0.10;p = 0.01)。

结论

单次全口非手术治疗对PiKS的长期管理有效,牙齿丧失率低。糖尿病、吸烟、晚期牙周炎阶段/分级以及更深的基线袋深度是TLP的关键预测因素。频繁进行SPT就诊可显著降低牙齿丧失风险。

临床意义

在(SPT)就诊期间,普遍的做法是对持续性牙周袋进行全口洁治,以破坏微生物群落,从而减少导致疾病进展的炎症反应。本研究调查了单次全口洁治作为SPT期间控制牙周疾病的标准做法的潜在替代方法的疗效,这对患者可能有潜在益处,包括减少治疗时间、提高对维持治疗的依从性以及牙周疾病的综合管理。通过尽量减少就诊次数,这种方法可能提高患者的依从性,同时降低各疗程之间未治疗部位再次感染的风险,最终有助于实现更好的长期牙周稳定性。诸如更深的基线探诊深度以及TLP的关键危险因素,包括糖尿病

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1618/12137392/aa6ffe9bf4a6/784_2025_6405_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1618/12137392/ecec3613b810/784_2025_6405_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1618/12137392/aa6ffe9bf4a6/784_2025_6405_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1618/12137392/ecec3613b810/784_2025_6405_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1618/12137392/aa6ffe9bf4a6/784_2025_6405_Fig2_HTML.jpg

相似文献

1
Effect of single-visit full-mouth non-surgical therapy and risk factor analysis on long-term periodontal treatment outcomes: aretrospective study.单次就诊全口非手术治疗对长期牙周治疗效果的影响及危险因素分析:一项回顾性研究
Clin Oral Investig. 2025 Jun 5;29(6):333. doi: 10.1007/s00784-025-06405-2.
2
Adjunctive antimicrobial photodynamic therapy for treating periodontal and peri-implant diseases.辅助抗菌光动力疗法治疗牙周病和种植体周围病。
Cochrane Database Syst Rev. 2024 Jul 12;7(7):CD011778. doi: 10.1002/14651858.CD011778.pub2.
3
Supportive periodontal therapy (SPT) for maintaining the dentition in adults treated for periodontitis.支持性牙周治疗(SPT)用于在接受牙周炎治疗的成年人中维持牙列。
Cochrane Database Syst Rev. 2018 Jan 1;1(1):CD009376. doi: 10.1002/14651858.CD009376.pub2.
4
Full-mouth treatment modalities (within 24 hours) for periodontitis in adults.成人牙周炎的全口治疗方法(24 小时内)。
Cochrane Database Syst Rev. 2022 Jun 28;6(6):CD004622. doi: 10.1002/14651858.CD004622.pub4.
5
Guided tissue regeneration for periodontal infra-bony defects.牙周骨下袋缺损的引导组织再生术。
Cochrane Database Syst Rev. 2006 Apr 19(2):CD001724. doi: 10.1002/14651858.CD001724.pub2.
6
Enamel matrix derivative (Emdogain) for periodontal tissue regeneration in intrabony defects. A Cochrane systematic review.釉基质衍生物(Emdogain)用于骨内缺损牙周组织再生的Cochrane系统评价。
Eur J Oral Implantol. 2009 Winter;2(4):247-66.
7
Non-surgical adjunctive interventions for accelerating tooth movement in patients undergoing orthodontic treatment.非手术辅助干预措施在正畸治疗中加速牙齿移动。
Cochrane Database Syst Rev. 2023 Jun 20;6(6):CD010887. doi: 10.1002/14651858.CD010887.pub3.
8
Interventions for replacing missing teeth: treatment of peri-implantitis.缺失牙修复干预措施:种植体周围炎的治疗
Cochrane Database Syst Rev. 2012 Jan 18;1(1):CD004970. doi: 10.1002/14651858.CD004970.pub5.
9
Enamel matrix derivative (Emdogain) for periodontal tissue regeneration in intrabony defects.釉基质衍生物(Emdogain)用于骨内缺损的牙周组织再生。
Cochrane Database Syst Rev. 2005 Oct 19(4):CD003875. doi: 10.1002/14651858.CD003875.pub2.
10
Treatment of periodontitis for glycaemic control in people with diabetes mellitus.糖尿病患者牙周炎治疗与血糖控制。
Cochrane Database Syst Rev. 2022 Apr 14;4(4):CD004714. doi: 10.1002/14651858.CD004714.pub4.

本文引用的文献

1
Non-Surgical Treatment of Moderate Periodontal Intrabony Defects With Adjunctive Cross-Linked Hyaluronic Acid: A Single-Blinded Randomized Controlled Clinical Trial.交联透明质酸辅助治疗中度牙周骨内缺损的非手术治疗:一项单盲随机对照临床试验。
J Clin Periodontol. 2025 Feb;52(2):310-322. doi: 10.1111/jcpe.14078. Epub 2024 Oct 14.
2
Impact of smoking on cost-effectiveness of 10-48 years of periodontal care.吸烟对10至48年牙周护理成本效益的影响。
Periodontol 2000. 2024 Jul 25. doi: 10.1111/prd.12585.
3
Residual vertical defects: risk of disease progression, retreatment rates, and cost: a retrospective analysis.
残留的垂直骨缺损:疾病进展风险、再治疗率和成本:回顾性分析。
Clin Oral Investig. 2024 Jul 25;28(8):446. doi: 10.1007/s00784-024-05849-2.
4
Ten-year prognostic outcomes of molar survival using the Miller-Mcentire Periodontal Prognostic Index - A longitudinal prospective study.使用米勒-麦肯蒂尔牙周预后指数评估磨牙生存率的十年预后结果——一项纵向前瞻性研究。
J Indian Soc Periodontol. 2024 Jan-Feb;28(1):75-78. doi: 10.4103/jisp.jisp_542_23. Epub 2024 Jun 4.
5
Influence of residual pockets on periodontal tooth loss: A retrospective analysis.残余牙周袋对牙周性牙齿缺失的影响:一项回顾性分析。
J Periodontol. 2024 May;95(5):444-455. doi: 10.1002/JPER.23-0448. Epub 2023 Dec 19.
6
Periodontitis stage and grade modifies the benefit of regular supportive periodontal care in terms of need for retreatment and mean cumulative cost.牙周炎分期和分级会影响定期牙周支持治疗在需要再治疗和平均累积成本方面的获益。
J Clin Periodontol. 2024 Feb;51(2):167-176. doi: 10.1111/jcpe.13909. Epub 2023 Dec 12.
7
Subgingival instrumentation.龈下器械操作
Periodontol 2000. 2023 May 10. doi: 10.1111/prd.12485.
8
Translating Clinical Outcomes to Patient Value Through Use of the Periodontal Risk Score: An Evidence-Based Treatment Approach.通过使用牙周风险评分将临床结果转化为患者价值:一种基于证据的治疗方法。
Compend Contin Educ Dent. 2023 Jan;44(1):18-24; quiz 25.
9
Smoking-induced microbial dysbiosis in health and disease.吸烟引起的健康和疾病相关的微生物失调。
Clin Sci (Lond). 2022 Sep 30;136(18):1371-1387. doi: 10.1042/CS20220175.
10
Periodontal risk score: Initiation and model validation for 6,762 teeth.牙周风险评分:6762 颗牙的起始和模型验证。
J Periodontol. 2023 Apr;94(4):459-466. doi: 10.1002/JPER.22-0273. Epub 2022 Nov 25.