Wang Yihao, Liu Zhen, Yi Dongye, Gu Sujie, Peng Zesheng, Wang Haofei, Lv Peng, Xiang Wei, Jiang Xiaobing, Fu Peng
Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Department of Neurosurgery, Henan Provincial People's Hospital, Zhengzhou 450000, China.
iScience. 2025 Apr 18;28(5):112473. doi: 10.1016/j.isci.2025.112473. eCollection 2025 May 16.
Glioma-associated mesenchymal stem cells (GA-MSCs), as a critical component of the glioma microenvironment, play an essential role in the development and invasion of glioma. Recent studies have shown that GA-MSCs can differentiate into pericytes under certain conditions, thereby promoting angiogenesis. However, the biological properties and molecular mechanisms underlying this process remain poorly understood. In the glioma microenvironment, our data revealed that the upregulation of Phosducin-like 3 () in GA-MSCs influences the expression of the downstream Vascular Endothelial Growth Factor Receptor 2 and pericyte markers, indicating a transformational relationship between GA-MSCs and pericytes. Furthermore, the vascular mimicry ability of co-cultured GA-MSCs and Human Umbilical Vein Endothelial Cells (HUVECs) is also significantly affected. Glioma induces the upregulation of expression in GA-MSCs, facilitating their transformation of GA-MSCs into pericytes and promoting tumor angiogenesis. These findings suggest that in GA-MSCs could serve as a potential target for anti-angiogenesis therapy in glioma.
胶质瘤相关间充质干细胞（GA-MSCs）作为胶质瘤微环境的关键组成部分，在胶质瘤的发生发展和侵袭中起着至关重要的作用。最近的研究表明，GA-MSCs在某些条件下可分化为周细胞，从而促进血管生成。然而，这一过程背后的生物学特性和分子机制仍知之甚少。在胶质瘤微环境中，我们的数据显示，GA-MSCs中类磷光蛋白3（）的上调会影响下游血管内皮生长因子受体2 和周细胞标志物的表达，表明GA-MSCs与周细胞之间存在转化关系。此外，共培养的GA-MSCs与人脐静脉内皮细胞（HUVECs）的血管拟态能力也受到显著影响。胶质瘤诱导GA-MSCs中 表达上调，促进GA-MSCs向周细胞转化并促进肿瘤血管生成。这些发现表明，GA-MSCs中的 可能成为胶质瘤抗血管生成治疗的潜在靶点。
