She Tianyu, Shah Nairuti, Jacob Benna, Starkman Nathan, Lieman Julie, Kaur Amandeep, Shah Neal, Wilkenfeld Marc
Department of Internal Medicine, NYU Grossman Long Island School of Medicine, Mineola, NY, USA.
Department of Gastroenterology, NYU Grossman Long Island School of Medicine, Mineola, NY, USA.
GE Port J Gastroenterol. 2024 Nov 7;32(3):151-160. doi: 10.1159/000541868. eCollection 2025 Jun.
Cholangiocarcinoma (CCA) is a malignancy that originates from the epithelial cells of the biliary system. Despite advancements in medical diagnostic techniques, CCAs remain a challenge to detect due to their silent clinical progression, making it difficult to diagnose these diseases. There are several well-established risk factors for CCA, including biliary tract infection and inflammation. However, there is also growing evidence that community and occupational exposures play a significant role in the development of bile duct cancers. This review examines the geographical distribution of these risk factors and the importance of surveillance in individuals exposed to these toxins who are more prone to developing CCA.
胆管癌（CCA）是一种起源于胆道系统上皮细胞的恶性肿瘤。尽管医学诊断技术有所进步，但由于CCA临床进展隐匿，其检测仍具有挑战性，这使得这些疾病难以诊断。CCA有几个已明确的危险因素，包括胆道感染和炎症。然而，越来越多的证据表明，社区和职业暴露在胆管癌的发生中起着重要作用。本综述探讨了这些危险因素的地理分布以及对接触这些毒素且更易患CCA的个体进行监测的重要性。
