Huang Jiawang, Jin Yucheng, Yi Zhigang
The Second Medical College of Lanzhou University, Lanzhou, China.
Lanzhou University Second Hospital, Lanzhou, China.
Front Endocrinol (Lausanne). 2025 May 21;16:1541601. doi: 10.3389/fendo.2025.1541601. eCollection 2025.
The Leucine-rich repeat-containing G protein-coupled receptor 4 (LGR4) is a member of the G protein-coupled receptor family and plays an important role in bone metabolism and tumor bone metastasis. LGR4 affects bone metabolism by regulating the differentiation and activity of osteoblasts and osteoclasts, and is involved in the balance between bone resorption and bone formation. Deficiency of LGR4 leads to osteoporosis, whereas the up-regulation of LGR4 may help to alleviate the development of traumatic osteoarthritis. Furthermore, in breast cancer and multiple myeloma, LGR4 promotes tumor cell metastasis to bone tissue by activating related signaling pathways. Therefore, LGR4 may be a potential target for the treatment of bone metabolic diseases and tumor bone metastasis.
富含亮氨酸重复序列的G蛋白偶联受体4（LGR4）是G蛋白偶联受体家族的成员，在骨代谢和肿瘤骨转移中起重要作用。LGR4通过调节成骨细胞和破骨细胞的分化及活性来影响骨代谢，并参与骨吸收与骨形成之间的平衡。LGR4缺乏会导致骨质疏松症，而LGR4的上调可能有助于缓解创伤性骨关节炎的发展。此外，在乳腺癌和多发性骨髓瘤中，LGR4通过激活相关信号通路促进肿瘤细胞向骨组织转移。因此，LGR4可能是治疗骨代谢疾病和肿瘤骨转移的潜在靶点。
