Morris J G
Med J Aust. 1985 Oct 14;143(8):347-50. doi: 10.5694/j.1326-5377.1985.tb123061.x.
In the management of Parkinson's disease physicians now have at their disposal a number of useful therapeutic tools (Figure 3). (Formula: see text) Anticholinergic drugs and amantadine suffice in the early stages of the disease when little disability is present. Levodopa combined with a peripheral decarboxylase inhibitor is the treatment of choice thereafter, and with the appearance of fluctuations it is necessary to increase the frequency of dosage of levodopa and to consider adding bromocriptine. Stereotactic surgery is useful in patients with severe tremor which is unresponsive to drug therapy.
在帕金森病的治疗中,医生现在有许多有用的治疗手段(图3)。(公式:见正文)在疾病早期,当几乎没有残疾时,抗胆碱能药物和金刚烷胺就足够了。此后,左旋多巴联合外周脱羧酶抑制剂是首选治疗方法,随着症状波动的出现,有必要增加左旋多巴的给药频率,并考虑加用溴隐亭。立体定向手术对药物治疗无效的严重震颤患者有用。