Brown Ashli A, Herrman Tim
Office of the Texas State Chemist, Texas A&M AgriLife Research, Texas A&M University System, College Station, TX 77841, United States.
Department of Soil and Crop Sciences, Interdisciplinary Faculty of Toxicology, Texas A&M University, College Station, TX 77843, United States.
Curr Res Toxicol. 2025 Apr 26;8:100235. doi: 10.1016/j.crtox.2025.100235. eCollection 2025.
In 2001, the US FDA released guidance levels (GLs) for fumonisin (FUM) in corn and corn by-products intended for human and animal consumption. Recent research challenges the conservatism of these GLs for ruminants, particularly for regions like the Texas High Plains, where blending permissions have been provoked, limiting the management of FUM contamination economically and maximization of corn availability for feedlots. This study evaluates whether scientific advancements since 2001 warrant a revision of these guidelines. Specifically, a 2020 study provides new data on cattle fed FUM concentrations up to 108.8 mg/kg, suggesting the current 60 mg/kg GL may be overly conservative. Using a combination of -analysis and the US EPA's Benchmark Dose Software (BMDS), we assess the new scientific evidence. Our findings indicate that new data does not significantly refine the dose-response relationship for FUM in cattle, supporting the continued appropriateness of the current 60 mg/kg GL.
2001年，美国食品药品监督管理局（FDA）发布了供人类和动物食用的玉米及玉米副产品中伏马菌素（FUM）的指导水平（GLs）。最近的研究对这些反刍动物GLs的保守性提出了质疑，特别是在德克萨斯高平原等地区，这些地区引发了混合许可问题，限制了对FUM污染的经济管理以及饲养场玉米供应的最大化。本研究评估自2001年以来的科学进展是否需要修订这些指南。具体而言，一项2020年的研究提供了关于喂食FUM浓度高达108.8毫克/千克的牛的新数据，表明当前60毫克/千克的GL可能过于保守。我们结合荟萃分析和美国环境保护局（EPA）的基准剂量软件（BMDS）来评估新的科学证据。我们的研究结果表明，新数据并未显著改善牛体内FUM的剂量反应关系，支持当前60毫克/千克GL的持续适用性。
