角质形成细胞衍生的糖皮质激素在皮肤屏障短暂受损期间维持免疫平衡。 - Suppr

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Keratinocyte-Derived Glucocorticoids Maintain Immune Balance During Transient Skin Barrier Perturbation.

作者信息

Phan Truong San, Lambrecht Rebekka, Merk Verena M, Wiedmann Alice, Zwicky Pascale, Becher Burkhard, Brunner Thomas

机构信息

Biochemical Pharmacology, Department of Biology, University of Konstanz, Konstanz, Germany.

Inflammation Research, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.

出版信息

Allergy. 2025 Aug;80(8):2384-2387. doi: 10.1111/all.16613. Epub 2025 Jun 5.

DOI:10.1111/all.16613

PMID:40470757

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12368758/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13e4/12368758/1c6ea276d0a4/ALL-80-2384-g001.jpg

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Allergy. 2024 Dec;79(12):3192-3237. doi: 10.1111/all.16318. Epub 2024 Oct 7.

Regulation of Tissue Immune Responses by Local Glucocorticoids at Epithelial Barriers and Their Impact on Interorgan Crosstalk.

Front Immunol. 2021 May 3;12:672808. doi: 10.3389/fimmu.2021.672808. eCollection 2021.

Does the epithelial barrier hypothesis explain the increase in allergy, autoimmunity and other chronic conditions?

Nat Rev Immunol. 2021 Nov;21(11):739-751. doi: 10.1038/s41577-021-00538-7. Epub 2021 Apr 12.

Keratinocytes control skin immune homeostasis through de novo-synthesized glucocorticoids.

Sci Adv. 2021 Jan 29;7(5). doi: 10.1126/sciadv.abe0337. Print 2021 Jan.

Extra-adrenal glucocorticoid synthesis at epithelial barriers.

Genes Immun. 2019 Nov;20(8):627-640. doi: 10.1038/s41435-019-0058-z. Epub 2019 Jan 29.

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Keratinocyte-Derived Glucocorticoids Maintain Immune Balance During Transient Skin Barrier Perturbation.

作者信息

Phan Truong San, Lambrecht Rebekka, Merk Verena M, Wiedmann Alice, Zwicky Pascale, Becher Burkhard, Brunner Thomas

机构信息

Biochemical Pharmacology, Department of Biology, University of Konstanz, Konstanz, Germany.

Inflammation Research, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.

出版信息

Allergy. 2025 Aug;80(8):2384-2387. doi: 10.1111/all.16613. Epub 2025 Jun 5.

DOI:10.1111/all.16613

PMID:40470757

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12368758/

Abstract

摘要

相似文献

Keratinocyte-Derived Glucocorticoids Maintain Immune Balance During Transient Skin Barrier Perturbation.

Allergy. 2025 Aug;80(8):2384-2387. doi: 10.1111/all.16613. Epub 2025 Jun 5.

Activation of transient receptor potential vanilloid 3 is required for keratinocyte differentiation and epidermal barrier formation.

Korean J Physiol Pharmacol. 2025 Jul 1;29(4):409-418. doi: 10.4196/kjpp.24.324. Epub 2025 Apr 28.

Keratinocytes control skin immune homeostasis through de novo-synthesized glucocorticoids.

Sci Adv. 2021 Jan 29;7(5). doi: 10.1126/sciadv.abe0337. Print 2021 Jan.

Keratinocyte-derived IL-1β induces PPARG downregulation and PPARD upregulation in human reconstructed epidermis following barrier impairment.

Exp Dermatol. 2021 Sep;30(9):1298-1308. doi: 10.1111/exd.14323. Epub 2021 Mar 18.

Skin - a vast organ with immunological function (Review).

Exp Ther Med. 2020 Jul;20(1):18-23. doi: 10.3892/etm.2020.8619. Epub 2020 Mar 20.

The AhR-Ovol1-Id1 regulatory axis in keratinocytes promotes epidermal and immune homeostasis in atopic dermatitis-like skin inflammation.

Cell Mol Immunol. 2025 Mar;22(3):300-315. doi: 10.1038/s41423-025-01264-z. Epub 2025 Feb 13.

Perturbation of epidermal barrier function correlates with initiation of cytokine cascade in human skin.

J Am Acad Dermatol. 1994 Apr;30(4):535-46. doi: 10.1016/s0190-9622(94)70059-1.

A role for Arginase in skin epithelial differentiation and anti-microbial peptide production.

Br J Dermatol. 2025 Feb 14. doi: 10.1093/bjd/ljaf057.

IL-13 modulates ∆Np63 levels causing altered expression of barrier- and inflammation-related molecules in human keratinocytes: A possible explanation for chronicity of atopic dermatitis.

Immun Inflamm Dis. 2021 Sep;9(3):734-745. doi: 10.1002/iid3.427. Epub 2021 Apr 1.

Keratinocytes regain momentum as instigators of cutaneous inflammation.

Trends Mol Med. 2006 Mar;12(3):102-6. doi: 10.1016/j.molmed.2006.01.001. Epub 2006 Jan 27.

本文引用的文献

The epithelial barrier theory and its associated diseases.

Allergy. 2024 Dec;79(12):3192-3237. doi: 10.1111/all.16318. Epub 2024 Oct 7.

Regulation of Tissue Immune Responses by Local Glucocorticoids at Epithelial Barriers and Their Impact on Interorgan Crosstalk.

Front Immunol. 2021 May 3;12:672808. doi: 10.3389/fimmu.2021.672808. eCollection 2021.

Does the epithelial barrier hypothesis explain the increase in allergy, autoimmunity and other chronic conditions?

Nat Rev Immunol. 2021 Nov;21(11):739-751. doi: 10.1038/s41577-021-00538-7. Epub 2021 Apr 12.

Keratinocytes control skin immune homeostasis through de novo-synthesized glucocorticoids.

Sci Adv. 2021 Jan 29;7(5). doi: 10.1126/sciadv.abe0337. Print 2021 Jan.

Extra-adrenal glucocorticoid synthesis at epithelial barriers.

Genes Immun. 2019 Nov;20(8):627-640. doi: 10.1038/s41435-019-0058-z. Epub 2019 Jan 29.

Cutaneous glucocorticosteroidogenesis: securing local homeostasis and the skin integrity.

Exp Dermatol. 2014 Jun;23(6):369-374. doi: 10.1111/exd.12376.