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抑制交流——经肛门自体间充质干细胞浸润促进前列腺癌根治术后直肠膀胱瘘修复

Curbing Communication - Transanal Infiltration of Autologous Mesenchymal Stem Cells Facilitating Rectovesical Fistula Repair After Radical Prostatectomy.

作者信息

Eberspacher Chiara, Lauro Augusto, Salomone Benedetta, Arcieri Francesco Leone, Arcieri Stefano, Mascagni Domenico

机构信息

Department of Surgery, "Sapienza" University of Rome, Viale Rena Elena 324, Rome, Italy.

出版信息

Dig Dis Sci. 2025 Jun 5. doi: 10.1007/s10620-025-09145-1.

Abstract

Treatment of acquired rectovesical or rectourethral fistula can be very challenging for surgeons. When a conservative approach fails, complex surgery is needed, with a substantial probability of complications and recurrences. In order to minimize the need for major surgery, autologous mesenchymal stem cells have been used to treat fistulas, especially in patients with inflammatory bowel diseases. We present a case of a patient with an iatrogenic rectovesical fistula that was successfully treated with transanal infiltration of mesenchymal stem cells around the rectal orifice of the fistula.

摘要

对于外科医生而言,后天性直肠膀胱瘘或直肠尿道瘘的治疗极具挑战性。当保守治疗方法失败时,就需要进行复杂的手术,且出现并发症和复发的可能性很大。为了尽量减少大型手术的必要性,自体间充质干细胞已被用于治疗瘘管,尤其是在患有炎症性肠病的患者中。我们报告一例医源性直肠膀胱瘘患者,通过在瘘管直肠开口周围经肛门浸润间充质干细胞成功治愈。

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