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Retraction: Receptor-Recognized α2-Macroglobulin Binds to Cell Surface-Associated GRP78 and Activates mTORC1 and mTORC2 Signaling in Prostate Cancer Cells.

出版信息

PLoS One. 2025 Jun 5;20(6):e0325675. doi: 10.1371/journal.pone.0325675. eCollection 2025.

DOI:10.1371/journal.pone.0325675
PMID:40471893
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12140203/
Abstract
摘要

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Retraction: Receptor-Recognized α2-Macroglobulin Binds to Cell Surface-Associated GRP78 and Activates mTORC1 and mTORC2 Signaling in Prostate Cancer Cells.撤稿声明：受体识别的α2-巨球蛋白与细胞表面相关的GRP78结合并激活前列腺癌细胞中的mTORC1和mTORC2信号通路。
PLoS One. 2025 Jun 5;20(6):e0325675. doi: 10.1371/journal.pone.0325675. eCollection 2025.
2
Receptor-recognized α₂-macroglobulin binds to cell surface-associated GRP78 and activates mTORC1 and mTORC2 signaling in prostate cancer cells.受体识别的α₂-巨球蛋白与细胞表面相关的 GRP78 结合，激活前列腺癌细胞中的 mTORC1 和 mTORC2 信号通路。
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Binding of activated alpha2-macroglobulin to its cell surface receptor GRP78 in 1-LN prostate cancer cells regulates PAK-2-dependent activation of LIMK.活化的α2-巨球蛋白与其在1-LN前列腺癌细胞表面的受体GRP78结合，可调节LIMK的PAK-2依赖性激活。
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Activated α2-Macroglobulin Regulates Transcriptional Activation of c-MYC Target Genes through Cell Surface GRP78 Protein.活化的α2-巨球蛋白通过细胞表面GRP78蛋白调节c-MYC靶基因的转录激活。
J Biol Chem. 2016 May 13;291(20):10904-15. doi: 10.1074/jbc.M115.708131. Epub 2016 Mar 21.
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Activated α2-macroglobulin binding to human prostate cancer cells triggers insulin-like responses.活化的α2-巨球蛋白与人类前列腺癌细胞结合会引发胰岛素样反应。
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Retraction: Activated α2-macroglobulin binding to cell surface GRP78 induces T-loop phosphorylation of Akt1 by PDK1 in association with raptor.撤回声明：活化的α2-巨球蛋白与细胞表面GRP78结合，通过与猛禽蛋白相关的3-磷酸肌醇依赖性蛋白激酶1诱导Akt1的T环磷酸化。
PLoS One. 2025 Jun 5;20(6):e0325677. doi: 10.1371/journal.pone.0325677. eCollection 2025.

引用本文的文献

1
Retraction: Activated α2-macroglobulin binding to cell surface GRP78 induces T-loop phosphorylation of Akt1 by PDK1 in association with raptor.撤回声明：活化的α2-巨球蛋白与细胞表面GRP78结合，通过与猛禽蛋白相关的3-磷酸肌醇依赖性蛋白激酶1诱导Akt1的T环磷酸化。
PLoS One. 2025 Jun 5;20(6):e0325677. doi: 10.1371/journal.pone.0325677. eCollection 2025.
2
Retraction: Evidence for a Pro-proliferative Feedback Loop in Prostate Cancer: The role of Epac1 and COX-2-dependent Pathways.撤稿声明：前列腺癌中促增殖反馈环的证据：Epac1和COX-2依赖途径的作用
PLoS One. 2025 Jun 5;20(6):e0325680. doi: 10.1371/journal.pone.0325680. eCollection 2025.

本文引用的文献

1
Retraction: Activated α2-macroglobulin binding to cell surface GRP78 induces T-loop phosphorylation of Akt1 by PDK1 in association with raptor.撤回声明：活化的α2-巨球蛋白与细胞表面GRP78结合，通过与猛禽蛋白相关的3-磷酸肌醇依赖性蛋白激酶1诱导Akt1的T环磷酸化。
PLoS One. 2025 Jun 5;20(6):e0325677. doi: 10.1371/journal.pone.0325677. eCollection 2025.
2
Retraction: Evidence for a Pro-proliferative Feedback Loop in Prostate Cancer: The role of Epac1 and COX-2-dependent Pathways.撤稿声明：前列腺癌中促增殖反馈环的证据：Epac1和COX-2依赖途径的作用
PLoS One. 2025 Jun 5;20(6):e0325680. doi: 10.1371/journal.pone.0325680. eCollection 2025.
3
Activated α2-macroglobulin binding to cell surface GRP78 induces T-loop phosphorylation of Akt1 by PDK1 in association with Raptor.活化的α2-巨球蛋白与细胞表面GRP78结合，通过PDK1与Raptor协同作用诱导Akt1的T环磷酸化。
PLoS One. 2014 Feb 6;9(2):e88373. doi: 10.1371/journal.pone.0088373. eCollection 2014.
4
Evidence for a pro-proliferative feedback loop in prostate cancer: the role of Epac1 and COX-2-dependent pathways.前列腺癌中促增殖反馈环的证据：Epac1 和 COX-2 依赖性途径的作用。
PLoS One. 2013 Apr 30;8(4):e63150. doi: 10.1371/journal.pone.0063150. Print 2013.
5
Receptor-recognized α₂-macroglobulin binds to cell surface-associated GRP78 and activates mTORC1 and mTORC2 signaling in prostate cancer cells.受体识别的α₂-巨球蛋白与细胞表面相关的 GRP78 结合，激活前列腺癌细胞中的 mTORC1 和 mTORC2 信号通路。
PLoS One. 2012;7(12):e51735. doi: 10.1371/journal.pone.0051735. Epub 2012 Dec 14.
6
Upregulation of mTORC2 activation by the selective agonist of EPAC, 8-CPT-2Me-cAMP, in prostate cancer cells: assembly of a multiprotein signaling complex.选择性 EPAC 激动剂 8-CPT-2Me-cAMP 上调前列腺癌细胞中 mTORC2 的激活：多蛋白信号复合物的组装。
J Cell Biochem. 2012 May;113(5):1488-500. doi: 10.1002/jcb.24018.
7
Loss of cell surface TFII-I promotes apoptosis in prostate cancer cells stimulated with activated α₂ -macroglobulin.细胞表面 TFII-I 的丢失促进了激活的 α₂-巨球蛋白刺激的前列腺癌细胞凋亡。
J Cell Biochem. 2011 Jun;112(6):1685-95. doi: 10.1002/jcb.23083.
8
Ligation of prostate cancer cell surface GRP78 activates a proproliferative and antiapoptotic feedback loop: a role for secreted prostate-specific antigen.前列腺癌细胞表面 GRP78 的结扎激活了一个促增殖和抗凋亡的反馈回路：分泌型前列腺特异性抗原的作用。
J Biol Chem. 2011 Jan 14;286(2):1248-59. doi: 10.1074/jbc.M110.129767. Epub 2010 Nov 5.
9
Ligation of cancer cell surface GRP78 with antibodies directed against its COOH-terminal domain up-regulates p53 activity and promotes apoptosis.用针对 GRP78 COOH 末端结构域的抗体交联癌细胞表面的 GRP78 会上调 p53 活性并促进细胞凋亡。
Mol Cancer Ther. 2009 May;8(5):1350-62. doi: 10.1158/1535-7163.MCT-08-0990. Epub 2009 May 5.
10
Activation and cross-talk between Akt, NF-kappaB, and unfolded protein response signaling in 1-LN prostate cancer cells consequent to ligation of cell surface-associated GRP78.细胞表面相关的GRP78连接后，1-LN前列腺癌细胞中Akt、核因子κB和未折叠蛋白反应信号之间的激活与相互作用
J Biol Chem. 2006 May 12;281(19):13694-13707. doi: 10.1074/jbc.M511694200. Epub 2006 Mar 16.