Liu Zongtai, Zhang Qingzheng, Li Yuehong, Wang Guoliang, Fu Changfeng, Sun Yirong, Ding Jianxun
Department of Spine Surgery, Center of Orthopedics, The First Hospital of Jilin University, 1 Xinmin Street, Changchun, 130061, PR China; State Key Laboratory of Polymer Science and Technology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, 130022, PR China.
State Key Laboratory of Polymer Science and Technology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, 130022, PR China.
Biomaterials. 2026 Jan;324:123426. doi: 10.1016/j.biomaterials.2025.123426. Epub 2025 May 23.
Intervertebral disc degeneration (IDD) is a widespread degenerative condition that significantly contributes to low back pain (LBP), neurological complications, and motor impairments. These effects profoundly reduce patients' quality of life and burden public health systems substantially. Current treatments, including conservative therapies and surgical interventions, have limited success in preventing further degeneration or restoring intervertebral disc (IVD) function. Advances in bioengineering, particularly biomaterial-based therapies, offer promising solutions for treating IDD. These approaches target key pathological mechanisms, such as cell loss, microenvironmental deterioration, and structural defects, aiming to halt disease progression and promote regeneration. This review explores the potential of biomaterial-based formulations for functional cell supplementation, extracellular microenvironment regulation, and structural reconstruction. Addressing interactions between innovative biomaterials and pathological features highlights their capacity to advance regenerative therapies for IDD, offering valuable insights for developing more effective treatments.
椎间盘退变（IDD）是一种普遍存在的退行性疾病，对腰痛（LBP）、神经并发症和运动功能障碍有显著影响。这些影响严重降低了患者的生活质量，并给公共卫生系统带来了沉重负担。目前的治疗方法，包括保守治疗和手术干预，在预防进一步退变或恢复椎间盘（IVD）功能方面取得的成功有限。生物工程的进展，特别是基于生物材料的治疗方法，为治疗IDD提供了有前景的解决方案。这些方法针对关键的病理机制，如细胞丢失、微环境恶化和结构缺陷，旨在阻止疾病进展并促进再生。本综述探讨了基于生物材料的制剂在功能性细胞补充、细胞外微环境调节和结构重建方面的潜力。探讨创新生物材料与病理特征之间的相互作用，凸显了它们推进IDD再生治疗的能力，为开发更有效的治疗方法提供了有价值的见解。
