Institute of Biomedical Sciences, Faculty of Medicine, University of Maribor, Maribor, Slovenia Laboratory of Inorganic Chemistry, Faculty of Chemistry and Chemical Technology, University of Maribor, Maribor, Slovenia.
Bosn J Basic Med Sci. 2019 May 20;19(2):130-137. doi: 10.17305/bjbms.2019.3778.
Intervertebral disc (IVD) degeneration (IDD) is associated with low back pain and significantly affects the patient's quality of life. Degeneration of the IVD alters disk height and the mechanics of the spine, leading to chronic segmental spinal instability. The pathophysiology of IVD disease is still not well understood. Current therapies for IDD include conservative and invasive approaches, but none of those treatments are able to restore the disc structure and function. Recently, tissue engineering techniques emerged as a possible approach to treat IDD, by replacing a damaged IVD with scaffolds and appropriate cells. Advances in manufacturing techniques, material processing and development, surface functionalization, drug delivery systems and cell incorporation furthered the development of tissue engineering therapies. In this review, biomaterial scaffolds and cell-based therapies for IVD regeneration are briefly discussed.
椎间盘（IVD）退变（IDD）与下腰痛有关，严重影响患者的生活质量。IVD 的退变改变了椎间盘的高度和脊柱的力学特性，导致慢性节段性脊柱不稳定。IVD 疾病的病理生理学仍不清楚。目前治疗 IDD 的方法包括保守治疗和有创治疗，但这些治疗方法都不能恢复椎间盘的结构和功能。最近，组织工程技术作为一种治疗 IDD 的可能方法出现，即用支架和合适的细胞替代受损的椎间盘。制造技术、材料加工和开发、表面功能化、药物输送系统和细胞结合方面的进步促进了组织工程治疗的发展。本文简要讨论了用于 IVD 再生的生物材料支架和基于细胞的治疗方法。
