Kim Lia, An Youn-Joo
Department of Environmental Health Science, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea.
Department of Environmental Health Science, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea.
Mar Pollut Bull. 2025 Oct;219:118255. doi: 10.1016/j.marpolbul.2025.118255. Epub 2025 Jun 4.
This study investigated the molecular effects of polyethylene terephthalate (PET) microfibers (MFs) on Penaeus vannamei, focusing on the length-dependent toxicological mechanisms. We exposed the shrimp to short (PETS, 240.55 μm) and long (PET-L, 2357.96 μm) PET MFs and analyzed the changes in transcriptomic and metabolomic profiles. PET-S posed greater risks than PET-L, leading to oxidative stress, disruption in nucleotide metabolism, and alterations in gene expression related to metabolic processes, including RNA methylation and purine metabolism. Conversely, PET-L caused abnormalities in intracellular signaling pathways and metabolic functions, including the downregulation of fatty acid oxidation and membrane transfer. Both PET-S and PET-L exposure impaired cellular functions, such as energy production and signal transduction. This multi-omics study highlights the toxicological mechanisms associated with PET MF exposure in a socioeconomically important marine organism.
本研究调查了聚对苯二甲酸乙二酯（PET）微纤维（MFs）对凡纳滨对虾的分子影响，重点关注长度依赖性毒理学机制。我们将虾暴露于短（PET-S，240.55μm）和长（PET-L，2357.96μm）的PET MFs中，并分析转录组和代谢组谱的变化。PET-S比PET-L带来更大的风险，导致氧化应激、核苷酸代谢紊乱以及与代谢过程相关的基因表达改变，包括RNA甲基化和嘌呤代谢。相反，PET-L导致细胞内信号通路和代谢功能异常，包括脂肪酸氧化和膜转运的下调。PET-S和PET-L暴露均损害了细胞功能，如能量产生和信号转导。这项多组学研究突出了在一种具有社会经济重要性的海洋生物中与PET MF暴露相关的毒理学机制。
