Amelia Meta, Siahaan Winnee Hana, Wijaya Nicholas, Harahap Arif Maulana, Rivany Mouza Abiyyu, Lumbanraja Sarma Nursani
Department of Center of Evidence Based Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, North Sumatera, Indonesia.
Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Sumatera Utara, Medan, North Sumatera, Indonesia.
Hypertens Pregnancy. 2025 Dec;44(1):2506451. doi: 10.1080/10641955.2025.2506451. Epub 2025 Jun 5.
Pre-eclampsia (PE) affects 2-8% of pregnant women and is a major cause of maternal and perinatal complications. Early risk identification is critical to reducing maternal and neonatal mortality and morbidity.
This systematic review evaluates the role of ophthalmic Doppler arteries parameters, combined with maternal risk factors, physical examination results, and laboratory results for PE screening.
Relevant articles were identified from PubMed, Wiley Online Library, and ScienceDirect using predefined inclusion and exclusion criteria. Articles were screened in two stages - primary extraction by title and abstract, followed by full-text evaluation. The final analysis included observational studies and randomized trials assessing PE prediction using ophthalmic Doppler artery indices.
Of the 103 records screened, 24 articles were retrieved, and 7 met the eligibility criteria. All studies examined ophthalmic artery Doppler parameters - especially the peak systolic velocity (PSV) ratio - for PE screening across different gestational ages. The PSV ratio showed moderate-to-high predictive value when combined with established clinical biomarkers.
The ophthalmic Doppler artery is regarded as a viable alternative or combination for early detection of PE that is simple to implement and effective, particularly in healthcare facilities in developing countries. However, further large-scale, externally validated studies are needed to establish its clinical utility across different gestational stages.
子痫前期（PE）影响2%-8%的孕妇，是孕产妇和围产期并发症的主要原因。早期风险识别对于降低孕产妇和新生儿死亡率及发病率至关重要。
本系统评价评估眼科多普勒动脉参数联合孕产妇风险因素、体格检查结果及实验室检查结果在子痫前期筛查中的作用。
使用预先定义的纳入和排除标准从PubMed、Wiley Online Library和ScienceDirect中检索相关文章。文章分两个阶段进行筛选——首先通过标题和摘要进行初步提取，然后进行全文评估。最终分析包括使用眼科多普勒动脉指数评估子痫前期预测的观察性研究和随机试验。
在筛选的103条记录中，检索到24篇文章，7篇符合纳入标准。所有研究均检测了眼科动脉多普勒参数——尤其是收缩期峰值流速（PSV）比值——用于不同孕周的子痫前期筛查。当与既定的临床生物标志物联合使用时，PSV比值显示出中到高的预测价值。
眼科多普勒动脉被认为是早期检测子痫前期的一种可行的替代方法或联合方法，实施简单且有效，尤其是在发展中国家的医疗机构中。然而，需要进一步开展大规模、外部验证的研究来确定其在不同孕周阶段的临床实用性。
