Hollis Emma L, Chronias Michael N, van Beek Carlijn L F, Gates Paul J, Collins Beatrice S L
School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS, UK.
Stratingh Institute for Chemistry, University of Groningen, Groningen, 9747 AG, The Netherlands.
Nat Commun. 2025 Jun 5;16(1):5232. doi: 10.1038/s41467-025-60383-3.
The controlled translational motion displayed by nature's motor proteins underpins a wealth of processes integral to life, from organelle transport to muscle contraction. The motor proteins move along one dimensional cytoskeletal tracks, with their motion characterised by high association of the enzyme to the biopolymer combined with highly dynamic motion along the track. Here we introduce carbon-to-carbon metal migration as a platform for dynamic association and show how such migrations, in combination with the incorporation of a simple hydrocarbon, can be harnessed to achieve autonomous directional translational motion of a metal centre along the length of a polyaromatic track.
自然界中的马达蛋白所展现出的可控平移运动，支撑着众多对生命至关重要的过程，从细胞器运输到肌肉收缩。这些马达蛋白沿着一维细胞骨架轨道移动，其运动的特点是酶与生物聚合物的高度结合以及沿轨道的高度动态运动。在此，我们引入碳 - 碳金属迁移作为动态结合的平台，并展示如何利用这种迁移，结合简单碳氢化合物的引入，来实现金属中心沿着多环芳烃轨道长度的自主定向平移运动。
