Zhao Wenlang, Wang Mingdan, Zhou Pan, Wang Ziyu, Deng Xuan, Li Jiangtao, Yang Na, Han Lizhen, Yang Zhao, Qi Yue, Liu Jing
Center for Clinical and Epidemiologic Research, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, National Clinical Research Center for Cardiovascular Diseases, Ministry of Education, Beijing, 100029, China.
J Hum Hypertens. 2025 Jun 5. doi: 10.1038/s41371-025-01034-4.
The multidimensional echocardiographic features associated with BP level are unclear. This study aimed to identify the multidimensional echocardiographic features associated with BP. In total, 2 092 adult participants (aged ≥18 years) with hypertension who underwent echocardiography in Beijing between July 2017 and January 2020 as part of the Multi-provincial Cohort for Hypertension study were enrolled. The associations between BP levels and echocardiographic features were investigated by multivariate regression analysis. After multivariable adjustment, a 1 SD (15.4 mmHg) increase in systolic BP was associated with a 0.21-mm increment (95% CI 0.06-0.35) in left atrial diameter, a 2.17-g/m increment (95% CI 1.46-2.88) in LV mass index, a 0.25-mm increment (95% CI 0.11-0.39) in ascending aorta diameter and a 0.03 decrement (95% CI -0.04, -0.01) in the E/A ratio. A 1 SD (10.1 mmHg) increase in diastolic BP was associated with a 1.51-g/m increment (95% CI 0.80-2.21) in LV mass index, a 0.46-mm increment (95% CI 0.31-0.61) in aortic root diameter, a 0.77-mm increment (95% CI 0.63-0.91) in ascending aorta diameter, and a 0.05 decrement (95% CI -0.07, -0.04) in E/A ratio. In conclusion, specific echocardiographic features were associated with the BP level. LV structure, ascending aorta diameter, and the E/A ratio were associated with systolic and diastolic BP. Left atrial diameter was positively associated only with systolic BP, and aortic root diameter was positively associated only with diastolic BP. These echocardiographic features may be valuable for early identification of target organ damage caused by elevated BP.
与血压水平相关的多维超声心动图特征尚不清楚。本研究旨在确定与血压相关的多维超声心动图特征。共有2092名年龄≥18岁的成年高血压患者参与了研究，他们于2017年7月至2020年1月在北京接受了超声心动图检查，作为多省高血压队列研究的一部分。通过多变量回归分析研究血压水平与超声心动图特征之间的关联。经过多变量调整后，收缩压每升高1个标准差（15.4mmHg），左心房直径增加0.21mm（95%CI 0.06 - 0.35），左心室质量指数增加2.17g/m（95%CI 1.46 - 2.88），升主动脉直径增加0.25mm（95%CI 0.11 - 0.39），E/A比值降低0.03（95%CI -0.04，-0.01）。舒张压每升高1个标准差（10.1mmHg），左心室质量指数增加1.51g/m（95%CI 0.80 - 2.21），主动脉根部直径增加0.46mm（95%CI 0.31 - 0.61），升主动脉直径增加0.77mm（95%CI 0.63 - 0.91），E/A比值降低0.05（95%CI -0.07，-0.04）。总之，特定的超声心动图特征与血压水平相关。左心室结构、升主动脉直径和E/A比值与收缩压和舒张压均相关。左心房直径仅与收缩压呈正相关，主动脉根部直径仅与舒张压呈正相关。这些超声心动图特征可能有助于早期识别血压升高引起的靶器官损害。
