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Sub-phenotyping in critical care: a valuable strategy or methodologically fragile path?

作者信息

Smit Jim M, Jonkman Annemijn H, Krijthe Jesse H

机构信息

Data Science Group, Institute for Computing and Information Sciences, Radboud University, Nijmegen, The Netherlands.

Pattern Recognition & Bioinformatics Group, Delft University of Technology, Delft, The Netherlands.

出版信息

Intensive Care Med Exp. 2025 Jun 5;13(1):59. doi: 10.1186/s40635-025-00769-1.

DOI:10.1186/s40635-025-00769-1
PMID:40473973
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12141183/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86a4/12141183/4dbb371aac26/40635_2025_769_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86a4/12141183/4dbb371aac26/40635_2025_769_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86a4/12141183/4dbb371aac26/40635_2025_769_Fig1_HTML.jpg

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本文引用的文献

[1]
Defining and subphenotyping ARDS: insights from an international Delphi expert panel.

Lancet Respir Med. 2025-7

[2]
Machine learning-based identification of efficient and restrictive physiological subphenotypes in acute respiratory distress syndrome.

Intensive Care Med Exp. 2025-3-1

[3]
Predicting benefit from adjuvant therapy with corticosteroids in community-acquired pneumonia: a data-driven analysis of randomised trials.

Lancet Respir Med. 2025-3

[4]
The Predictive Approaches to Treatment effect Heterogeneity (PATH) Statement.

Ann Intern Med. 2019-11-12

[5]
Subphenotypes in acute respiratory distress syndrome: latent class analysis of data from two randomised controlled trials.

Lancet Respir Med. 2014-5-19

[6]
Higher vs lower positive end-expiratory pressure in patients with acute lung injury and acute respiratory distress syndrome: systematic review and meta-analysis.

JAMA. 2010-3-3

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