Salerno L, Sallì L, Pepe S, Curiale B, Allegra G, Scalici G, Salvato F
Minerva Med. 1985 Sep 22;76(36):1611-8.
Research has been carried out into the effects of a new vasoactive substance, buflomedil hydrochloride, on two groups of patients suffering from cerebrovascular insufficiency and obliterating arteriopathy at the lower extremities. Ten clinical parameters were assessed in the first group of patients (insomnia, headache, vertigo, tinnitus, asthenia, shaking, changes in reflexes, anorexia, memory disturbances, problems of concentration and character disturbances); in the second group, the muscular flow of the gastrocnemius as measured by the muscular clearance of NaI131 at rest, during standard exercise conditions, during ten minutes following exercise and in the post-ischaemic phase. The results can be considered satisfactory in both groups, especially after prolonged treatment and in the early stage of the disease. Drug tolerance was very good.
已对一种新型血管活性物质盐酸丁咯地尔对两组患有脑血管供血不足和下肢闭塞性动脉病的患者的影响进行了研究。对第一组患者评估了十个临床参数（失眠、头痛、眩晕、耳鸣、乏力、震颤、反射变化、厌食、记忆障碍、注意力问题和性格障碍）；对第二组患者，在静息状态、标准运动条件下、运动后十分钟以及缺血后阶段，通过 NaI131 的肌肉清除率测量了腓肠肌的肌肉血流量。两组的结果均可认为是令人满意的，尤其是在长期治疗后以及疾病早期。药物耐受性非常好。
